prikaz prve stranice dokumenta Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
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Scientific paper - Original scientific paper
Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
Immunity, 40 (2014), 6; 961-973. https://doi.org/10.1016/j.immuni.2014.05.003
Crouse, Josh; Bedenikovic, Gregor; Wiesel, Melanie; Ibberson, Mark; Xenarios, Ioannis; Von Laer, Dorothee; Kalinke, Ulrich; Vivier, Eric; Jonjić, Stipan; Oxenius, Annette

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Crouse, J., Bedenikovic, G., Wiesel, M., Ibberson, M., Xenarios, I., Von Laer, D. ... Oxenius, A. (2014). Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity, 40. (6), 961-973. doi: 10.1016/j.immuni.2014.05.003

Crouse, Josh, et al. "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1." Immunity, vol. 40, no. 6, 2014, pp. 961-973. https://doi.org/10.1016/j.immuni.2014.05.003

Crouse, Josh, Gregor Bedenikovic, Melanie Wiesel, Mark Ibberson, Ioannis Xenarios, Dorothee Von Laer, Ulrich Kalinke, Eric Vivier, Stipan Jonjić and Annette Oxenius. "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1." Immunity 40, no. 6 (2014): 961-973. https://doi.org/10.1016/j.immuni.2014.05.003

Crouse, J., et al. (2014) 'Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1', Immunity, 40(6), pp. 961-973. doi: 10.1016/j.immuni.2014.05.003

Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, and sur.. Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity [Internet]. 2014 June [cited 2024 November 26];40(6):961-973. doi: 10.1016/j.immuni.2014.05.003

J. Crouse, et al., "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1", Immunity, vol. 40, no. 6, pp. 961-973, June 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:143323. [Accessed: 26 November 2024]

Metadata
Title (english)Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
AuthorJosh Crouse
AuthorGregor Bedenikovic
AuthorMelanie Wiesel
AuthorMark Ibberson
AuthorIoannis Xenarios
AuthorDorothee Von Laer
AuthorUlrich Kalinke
AuthorEric Vivier
AuthorStipan Jonjić
AuthorAnnette Oxenius
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion, differentiation, and survival of responding T cells following infection with viruses prominently inducing type I IFN. The reasons for the abortive response of T cells lacking the type I IFN receptor (Ifnar1(-/-)) remain unclear. We report here that Ifnar1(-/-) T cells were highly susceptible to natural killer (NK) cell-mediated killing in a perforin-dependent manner. Depletion of NK cells prior to lymphocytic choriomeningitis virus (LCMV) infection completely restored the early expansion of Ifnar1(-/-) T cells. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 40, no. 6, pp. 961-973
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2014.05.003
URN:NBNurn:nbn:hr:184:143323
Publication2014-06
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 268537
Title (english): The Immune function of NK cells
Acronym: THINK
Jurisdiction: eu
Funding stream: FP7
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1074761314001812
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-22 22:04:23