prikaz prve stranice dokumenta Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
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Scientific paper - Original scientific paper
Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
PLOS Pathogens, 11 (2015), 2; e1004640. https://doi.org/10.1371/journal.ppat.1004640
Lemmermann, Niels A. W.; Krmpotić, Astrid; Podlech, Jürgen; Brizić, Ilija; Prager, Adrian; Adler, Heiko; Karbach, Astrid; Wu, Yiquan; Jonjić, Stipan; Reddehase, Matthias J.; Adler, Barbara

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Lemmermann, N. A. W., Krmpotić, A., Podlech, J., Brizić, I., Prager, A., Adler, H. ... Adler, B. (2015). Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread. PLOS Pathogens, 11. (2). doi: 10.1371/journal.ppat.1004640

Lemmermann, Niels A. W., et al. "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread." PLOS Pathogens, vol. 11, no. 2, 2015. https://doi.org/10.1371/journal.ppat.1004640

Lemmermann, Niels A. W., Astrid Krmpotić, Jürgen Podlech, Ilija Brizić, Adrian Prager, Heiko Adler, Astrid Karbach, et al. "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread." PLOS Pathogens 11, no. 2 (2015). https://doi.org/10.1371/journal.ppat.1004640

Lemmermann, N. A. W., et al. (2015) 'Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread', PLOS Pathogens, 11(2). doi: 10.1371/journal.ppat.1004640

Lemmermann NAW, Krmpotić A, Podlech J, Brizić I, Prager A, Adler H, and sur.. Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread. PLOS Pathogens [Internet]. 2015 February 06 [cited 2024 November 23];11(2). doi: 10.1371/journal.ppat.1004640

N. A. W. Lemmermann, et al., "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread", PLOS Pathogens, vol. 11, no. 2, February 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:358483. [Accessed: 23 November 2024]

Metadata
Title (english)Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
AuthorNiels A. W. Lemmermann
AuthorAstrid Krmpotić
AuthorJürgen Podlech
AuthorIlija Brizić
AuthorAdrian Prager
AuthorHeiko Adler
AuthorAstrid Karbach
AuthorYiquan Wu
AuthorStipan Jonjić
AuthorMatthias J. Reddehase
AuthorBarbara Adler
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Author Summary The role of viral glycoprotein entry complexes in viral tropism in vivo is a question central to understanding virus pathogenesis and transmission for any virus. Studies were limited by the difficulty in distinguishing between viral entry into first-hit target cells and subsequent cell-to-cell spread within tissues. Employing the murine cytomegalovirus entry complex gH/gL/gO as a paradigm for a generally applicable strategy to dissect these two events experimentally, we used a gO-transcomplemented ΔgO mutant for providing the complex exclusively for the initial cell entry step. In immunocompromised mice as a model for recipients of hematopoietic cell transplantation, our studies revealed an irreplaceable role for gH/gL/gO in initiating infection in host organs relevant to pathogenesis, whereas subsequent spread within tissues and infection of the salivary glands, the site relevant to virus host-to-host transmission, are double-secured by the entry complexes gH/gL/gO and gH/gL/MCK-2. As an important consequence, interventional strategies targeting only gO might be efficient in preventing organ manifestations after a primary viremia, whereas both gH/gL complexes need to be targeted for preventing intra-tissue spread of virus reactivated from latency within tissues as well as for preventing the salivary gland route of host-to-host transmission.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS Pathogens
Numberingvol. 11, no. 2, e1004640
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004640
URN:NBNurn:nbn:hr:184:358483
Publication2015-02-06
ProjectNumber: IP-2013-11-7132
Title (croatian): Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa
Acronym: ViSpeNKRec
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://dx.plos.org/10.1371/journal.ppat.1004640
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2018-11-27 17:36:31