prikaz prve stranice dokumenta Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus
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Scientific paper - Original scientific paper
Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus
Journal of Virology, 78 (2004), 14; 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004
Bubić, Ivan; Wagner, M.; Krmpotić, Astrid; Saulig, T.; Kim, S.; Yokoyama, W. M.; Jonjić, Stipan; Koszinowski, U. H.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bubić, I., Wagner, M., Krmpotić, A., Saulig, T., Kim, S., Yokoyama, W. M. ... Koszinowski, U. H. (2004). Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus. Journal of Virology, 78. (14), 7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

Bubić, Ivan, et al. "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus." Journal of Virology, vol. 78, no. 14, 2004, pp. 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004

Bubić, Ivan, M. Wagner, Astrid Krmpotić, T. Saulig, S. Kim, W. M. Yokoyama, Stipan Jonjić and U. H. Koszinowski. "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus." Journal of Virology 78, no. 14 (2004): 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004

Bubić, I., et al. (2004) 'Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus', Journal of Virology, 78(14), pp. 7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

Bubić I, Wagner M, Krmpotić A, Saulig T, Kim S, Yokoyama WM, and sur.. Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus. Journal of Virology [Internet]. 2004 June 25 [cited 2024 November 23];78(14):7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

I. Bubić, et al., "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus", Journal of Virology, vol. 78, no. 14, pp. 7536-7544, June 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:100329. [Accessed: 23 November 2024]

Metadata
Title (english)Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus
AuthorIvan Bubić
AuthorM. Wagner
AuthorAstrid Krmpotić
AuthorT. Saulig
AuthorS. Kim
AuthorW. M. Yokoyama
AuthorStipan Jonjić
AuthorU. H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Mouse strains are either resistant or susceptible to murine cytomegalovirus (MCMV). Resistance is determined by the Cmv1r (Ly49h) gene, which encodes the Ly49H NK cell activation receptor. The protein encoded by the m157 gene of MCMV has been defined as a ligand for Ly49H. To find out whether the m157 protein is the only Ly49H ligand encoded by MCMV, we constructed the m157 deletion mutant and a revertant virus. Viruses were tested for susceptibility to NK cell control in Ly49H and Ly49H mouse strains. Deletion of the m157 gene abolished the viral activation of Ly49H NK cells, resulting in higher virus virulence in vivo. Thus, in the absence of m157, Ly49H mice react like susceptible strains. 129/SvJ mice lack the Ly49H activation NK cell receptor but express the inhibitory Ly49I NK cell receptor that binds to the m157 protein. The m157 inhibitory phenotype was weak because MCMV encodes a number of proteins that mediate NK inhibition, whose contribution could be shown by another mutant.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 78, no. 14, pp. 7536-7544
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.78.14.7536-7544.2004
URN:NBNurn:nbn:hr:184:100329
Publication2004-06-25
Publication2004-07-15
Document URLhttp://jvi.asm.org/cgi/doi/10.1128/JVI.78.14.7536-7544.2004
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-28 09:26:06