prikaz prve stranice dokumenta Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
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Scientific paper - Original scientific paper
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Proceedings of the National Academy of Sciences, 109 (2012), 50; 20467-20472. https://doi.org/10.1073/pnas.1218535109
Bursać, Slađana; Brdovčak Cokarić, Maja; Pfannkuchen, Martin; Oršolic, Ines; Golomb, L.; Zhu, Y.; Katz, C.; Daftuar, L.; Grabušić, Kristina; Vukelić, Iva; Filić, Vedrana; Oren, M.; Prives, C.; Volarević, Siniša

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Bursać, S., Brdovčak Cokarić, M., Pfannkuchen, M., Oršolic, I., Golomb, L., Zhu, Y. ... Volarević, S. (2012). Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences, 109. (50), 20467-20472. doi: 10.1073/pnas.1218535109

Bursać, Slađana, et al. "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress." Proceedings of the National Academy of Sciences, vol. 109, no. 50, 2012, pp. 20467-20472. https://doi.org/10.1073/pnas.1218535109

Bursać, Slađana, Maja Brdovčak Cokarić, Martin Pfannkuchen, Ines Oršolic, L. Golomb, Y. Zhu, C. Katz, et al. "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress." Proceedings of the National Academy of Sciences 109, no. 50 (2012): 20467-20472. https://doi.org/10.1073/pnas.1218535109

Bursać, S., et al. (2012) 'Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress', Proceedings of the National Academy of Sciences, 109(50), pp. 20467-20472. doi: 10.1073/pnas.1218535109

Bursać S, Brdovčak Cokarić M, Pfannkuchen M, Oršolic I, Golomb L, Zhu Y, and sur.. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences [Internet]. 2012 November 20 [cited 2024 May 18];109(50):20467-20472. doi: 10.1073/pnas.1218535109

S. Bursać, et al., "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress", Proceedings of the National Academy of Sciences, vol. 109, no. 50, pp. 20467-20472, November 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:046759. [Accessed: 18 May 2024]

Metadata
Title (english)Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
AuthorSlađana Bursać
AuthorMaja Brdovčak Cokarić
AuthorMartin Pfannkuchen
AuthorInes Oršolic
AuthorL. Golomb
AuthorY. Zhu
AuthorC. Katz
AuthorL. Daftuar
AuthorKristina Grabušić
AuthorIva Vukelić
AuthorVedrana Filić
AuthorM. Oren
AuthorC. Prives
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in p53 activation under these conditions. Here, we report that L5 and L11 are particularly important for this response. Whereas several other newly synthesized ribosomal proteins are degraded by proteasomes upon inhibition of Pol I activity by actinomycin D, L5 and L11 accumulate in the ribosome-free fraction where they bind to Mdm2. This selective accumulation of free L5 and L11 is due to their mutual protection from proteasomal degradation. Furthermore, the endogenous, newly synthesized L5 and L11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with Mdm2, p53, and promyelocytic leukemia protein. This suggests that the disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress. These findings may have important implications with respect to understanding the pathogenesis of diseases caused by impaired ribosome biogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 109, no. 50, pp. 20467-20472
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1218535109
URN:NBNurn:nbn:hr:184:046759
Publication2012-11-20
Publication2012-12-11
ProjectNumber: 062-1081347-0370
Title (croatian): Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo
Leader: Siniša Volarević
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://www.pnas.org/cgi/doi/10.1073/pnas.1218535109
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-29 22:52:29