prikaz prve stranice dokumenta A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis
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Scientific paper - Original scientific paper
A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis
ImmunoHorizons, 1 (2017), 9; 198-212. https://doi.org/10.4049/immunohorizons.1700011
Trembath, Andrew P.; Sharma, Neekun; Raju, Saravanan; Polić, Bojan; Markiewicz, Mary A.

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Trembath, A. P., Sharma, N., Raju, S., Polić, B. & Markiewicz, M. A. (2017). A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis. ImmunoHorizons, 1. (9), 198-212. doi: 10.4049/immunohorizons.1700011

Trembath, Andrew P., et al. "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis." ImmunoHorizons, vol. 1, no. 9, 2017, pp. 198-212. https://doi.org/10.4049/immunohorizons.1700011

Trembath, Andrew P., Neekun Sharma, Saravanan Raju, Bojan Polić and Mary A. Markiewicz. "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis." ImmunoHorizons 1, no. 9 (2017): 198-212. https://doi.org/10.4049/immunohorizons.1700011

Trembath, A. P., et al. (2017) 'A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis', ImmunoHorizons, 1(9), pp. 198-212. doi: 10.4049/immunohorizons.1700011

Trembath AP, Sharma N, Raju S, Polić B, Markiewicz MA. A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis. ImmunoHorizons [Internet]. 2017 November 07 [cited 2024 November 09];1(9):198-212. doi: 10.4049/immunohorizons.1700011

A. P. Trembath, N. Sharma, S. Raju, B. Polić and M. A. Markiewicz, "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis", ImmunoHorizons, vol. 1, no. 9, pp. 198-212, November 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:810946. [Accessed: 09 November 2024]

Metadata
Title (english)A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis
AuthorAndrew P. Trembath
AuthorNeekun Sharma
AuthorSaravanan Raju https://orcid.org/0000-0001-8904-8497
AuthorBojan Polić
AuthorMary A. Markiewicz https://orcid.org/0000-0001-5685-8573
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The NK group 2 member D (NKG2D) immune receptor is implicated in both human and mouse autoimmune diabetes. However, the significance of NKG2D in diabetes pathogenesis has been unclear due to conflicting reports as to the importance of this receptor in the NOD mouse model. In this study we demonstrate that NKG2D expression affects NOD diabetes development by at least two previously undescribed, and opposing, mechanisms. First, we demonstrate that the NKG2D ligand H60a is induced on activated NOD T cells, and that NKG2D–H60a interaction during CD8+ T cell differentiation into CTLs generally decreases the subsequent CTL effector cytokine response. This corresponds to an increase in diabetes development in NKG2D-deficient compared with wild-type NOD mice under microbiota-depleted conditions. Second, we demonstrate that NKG2D promotes NOD diabetes development through interaction with the microbiota. Together these findings reveal a previously undescribed role for NKG2D ligand expression by activated T cells in CTL development. Further, they demonstrate that NKG2D has both diabetogenic and antidiabetogenic roles in NOD diabetes development.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunoHorizons
Numberingvol. 1, no. 9, pp. 198-212
e-ISSN2573-7732
DOIhttps://doi.org/10.4049/immunohorizons.1700011
URN:NBNurn:nbn:hr:184:810946
Publication2017-11-07
Publication2017-11-01
Document URLhttp://www.immunohorizons.org/lookup/doi/10.4049/immunohorizons.1700011
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-11-30 07:21:48