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Scientific paper - review paper
Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities
Open Access Journal of Biomedical Engineering and Biosciences, 2 (2018), 5; 230-236. https://doi.org/10.32474/OAJBEB.2018.02.000147
Batičić Pučar, Lara; Sharbini, Alaa; Varljen, Jadranka; Pernjak Pugel, Ester; Grčić, Antonijo; Detel, Dijana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Batičić Pučar, L., Sharbini, A., Varljen, J., Pernjak Pugel, E., Grčić, A. & Detel, D. (2018). Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities. Open Access Journal of Biomedical Engineering and Biosciences, 2. (5), 230-236. doi: 10.32474/OAJBEB.2018.02.000147

Batičić Pučar, Lara, et al. "Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities." Open Access Journal of Biomedical Engineering and Biosciences, vol. 2, no. 5, 2018, pp. 230-236. https://doi.org/10.32474/OAJBEB.2018.02.000147

Batičić Pučar, Lara, Alaa Sharbini, Jadranka Varljen, Ester Pernjak Pugel, Antonijo Grčić and Dijana Detel. "Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities." Open Access Journal of Biomedical Engineering and Biosciences 2, no. 5 (2018): 230-236. https://doi.org/10.32474/OAJBEB.2018.02.000147

Batičić Pučar, L., et al. (2018) 'Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities', Open Access Journal of Biomedical Engineering and Biosciences, 2(5), pp. 230-236. doi: 10.32474/OAJBEB.2018.02.000147

Batičić Pučar L, Sharbini A, Varljen J, Pernjak Pugel E, Grčić A, Detel D. Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities. Open Access Journal of Biomedical Engineering and Biosciences [Internet]. 2018 September 10 [cited 2024 November 27];2(5):230-236. doi: 10.32474/OAJBEB.2018.02.000147

L. Batičić Pučar, A. Sharbini, J. Varljen, E. Pernjak Pugel, A. Grčić and D. Detel, "Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities", Open Access Journal of Biomedical Engineering and Biosciences, vol. 2, no. 5, pp. 230-236, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:786960. [Accessed: 27 November 2024]

Metadata
Title (english)Diabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities
AuthorLara Batičić Pučar
AuthorAlaa Sharbini
AuthorJadranka Varljen
AuthorEster Pernjak Pugel
AuthorAntonijo Grčić
AuthorDijana Detel
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Hyperglycemia, often accompanied with various complications such as chronic ulcers, represents a major socio-economic health problem. Dipeptidyl peptidase IV or CD26 molecule (DPP IV/CD26), is an omnipresent transmembrane protein with significant involvements in different physiological and pathological processes. It has been recognized as a therapeutic option in the treatment of hyperglycemia, especially in patients suffering from type 2 diabetes, given its capability to regulate the biological activity of incretins, which are major regulators of glucose homeostasis. Furthermore, DPP IV/CD26 has been indicated to be involved in the regulation of inflammatory processes as well as cell proliferation and angiogenesis. New scientific evidence shows that inhibition of DPP IV/CD26 leads to a more efficacious healing of chronic ulcers in diabetic patients as well as in mice models of wounded tissue restoration. However, the role of DPP IV/CD26 in the process of wound healing in hyperglycemia is not entirely known. Our aim was to summarize most important findings on the involvement of DPP IV/CD26 in the regulation of glycemia as well as tissue regeneration and reparation. This work reviews basic biochemical.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOpen Access Journal of Biomedical Engineering and Biosciences
Numberingvol. 2, no. 5, pp. 230-236
e-ISSN2637-4579
DOIhttps://doi.org/10.32474/OAJBEB.2018.02.000147
URN:NBNurn:nbn:hr:184:786960
Publication2018-09-10
Document URLhttps://www.lupinepublishers.com/biomedical-sciences-journal/fulltext/diabetes-dipeptidyl-peptidase-iv-and-wound-healing-from-basic-science-to-therapeutic-possibilities.ID.000147.php
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-12-03 15:13:36