prikaz prve stranice dokumenta Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
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Scientific paper - Original scientific paper
Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
Clinical Kidney Journal, 10 (2017), 6; 852-858. https://doi.org/10.1093/ckj/sfx050
Katalinić, Nataša; Starčević, Alma; Mavrinac, Martina; Balen, Sanja

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Katalinić, N., Starčević, A., Mavrinac, M. & Balen, S. (2017). Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events. Clinical Kidney Journal, 10. (6), 852-858. doi: 10.1093/ckj/sfx050

Katalinić, Nataša, et al. "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events." Clinical Kidney Journal, vol. 10, no. 6, 2017, pp. 852-858. https://doi.org/10.1093/ckj/sfx050

Katalinić, Nataša, Alma Starčević, Martina Mavrinac and Sanja Balen. "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events." Clinical Kidney Journal 10, no. 6 (2017): 852-858. https://doi.org/10.1093/ckj/sfx050

Katalinić, N., et al. (2017) 'Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events', Clinical Kidney Journal, 10(6), pp. 852-858. doi: 10.1093/ckj/sfx050

Katalinić N, Starčević A, Mavrinac M, Balen S. Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events. Clinical Kidney Journal [Internet]. 2017 December [cited 2024 April 28];10(6):852-858. doi: 10.1093/ckj/sfx050

N. Katalinić, A. Starčević, M. Mavrinac and S. Balen, "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events", Clinical Kidney Journal, vol. 10, no. 6, pp. 852-858, December 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:698119. [Accessed: 28 April 2024]

Metadata
Title (english)Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
AuthorNataša Katalinić
AuthorAlma Starčević
AuthorMartina Mavrinac
AuthorSanja Balen
MBZ: 236875
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Informatics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: The aim of this study was to determine the frequency of exposure to different sensitizing events (SEs) and to assess their effects on human leucocyte antigen (HLA) alloimmunization in transplant candidates using two different HLA antibody screening techniques: complement-dependent cytotoxicity (CDC) and Luminex. Methods: This retrospective study included HLA antibody screening results for 163 patients on the kidney transplant waiting list (WL) tested from March 2012 until the end of December 2015 at the Tissue Typing Laboratory, Rijeka, Croatia. All sera samples were tested using the CDC and Luminex techniques in parallel. Results: Two-thirds of the patients [114 (70%)] on the WL were exposed to transfusions, pregnancies and/or kidney transplant. The pre-transplant sera of 104 (63.80%) patients were negative for antibodies. In the sera of 23 (14.11%) patients, HLA antibodies were detected by CDC and Luminex and in the sera of 36 (22.09%) patients by Luminex only. Conclusion: In patients on kidney WL, previous organ transplantation represents the strongest immunogenic stimulus, followed by blood transfusions (the most frequent SE) and pregnancies. Although Luminex is more sensitive than CDC in HLA antibody detection, the decision on unacceptable HLA antigens in WL patients has to be based on the results of both assays and the patient’s immunization history.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical Kidney Journal
Numberingvol. 10, no. 6, pp. 852-858
p-ISSN2048-8505
e-ISSN2048-8513
DOIhttps://doi.org/10.1093/ckj/sfx050
URN:NBNurn:nbn:hr:184:698119
Publication2017-12
Publication2017-12-01
Publication2017-07-25
Document URLhttp://academic.oup.com/ckj/article/10/6/852/4036278
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2018-12-04 11:33:39