Title GASTROSHIZA - NOVI ASPEKTI LIJEČENJA
Title (english) GASTROSCHISIS - NEW ASPECTS OF TREATMENT
Author Lucija Milolović
Mentor Harry Nikolić (mentor)
Committee member Nado Bukvić (predsjednik povjerenstva)
Committee member Aldo Ivančić (član povjerenstva)
Committee member Srećko Severinski (član povjerenstva)
Granter University of Rijeka Faculty of Medicine (Department of Surgery) Rijeka
Defense date and country 2018-07-13, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Surgery
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Pediatrics
Abstract Gastoshiza (GS) je kongenitalna anomalija trbušne stijenke koja je povijesno tretirana na hitnoj osnovi primarnim zatvaranjem ili u slučaju abdominalnovisceralne disproporcije, silikonskim vrećicama. Incidencija GS povećava se širom svijeta, 4-5:10000 novorođenčadi. Postotak preživljavanja je viši od 90% tijekom posljednjih 6 desetljeća, zbog poboljšanih tehnika zatvaranae defekta abdominalnih zidova i napretka u neonatalnoj skrbi. Unatoč napretku, postkirurška skrb ostaje izazov, a gastroshiza i dalje ostaje kongenitalna mana s najdužim boravkom u JIL-u. Tri su kirurške tehnike koje se korište: primarno operativno zatvaranje, odgođeno zatvaranje umjetnim materijalima ili upotreba silikonskih vrećica. Novije silikonske vrećice korištene su kao tehnika spašavanja kod pacijenata koji su primarno operativno zatorili defekt ili kao inicijalnu terapiju koja bi omogućila pokrivanje crijeva uz konačno zatvaranje kasnije. Silikonske vrećice omogućuju smanjenje edema crijeva, čime se smanjuje i intraabdominalni tlak u vrijeme konačnog fascijskog zatvaranja. Poboljšava splanhičnu cirkulaciju koja rezultira bržim povratkom crijevne funkcije, smanjenom stopom infekcije i nekrotizirajućim enterokolitisom. GS je povezana s abnormalnom pokretljivošću crijeva i apsorpcijom hranjivih tvari, od kojih se oba postupno poboljšavaju u većini pacijenata. Uvođenje enteralnog hranjenja često se odgađa tjednima dok crijeva nisu funkcionalna. Tijekom tog razdoblja potrebna je nazgastrična dekompresija i parenteralna prehrana. Kada se pojavi crijevna aktivnost, započinje se s enteralnom ishranom. Preporuča se rana oralna stimulacija kako bi se spriječio gubitak refluksa sisanja. Prisutnost kompleksne bolesti najvažnija je prognostička odrednica za slab ishod.
Abstract (english) Gastroschisis (GS) is a congenital anomaly of the abdominal wall that has historically been treated on an emergency basis by primary closure or, in the case of abdominovisceral disproportion, by surgical silo placement. Incidence of GS is increasing worldwide, affecting 4–5/10,000 newborns. Survival has dramatically improved to greater than 90% over the past 6 decades, due to improved techniques to close the abdominal wall defect and advances in neonatal care. Despite these advances, post-surgical care for gastroschisis remains challenging, and gastroschisis is the congenital defect with the longest intensive care unit of stay. Three surgical techniques have been mostly use: primary fascial closure, staged repair with a silo, and „umbilical turban“ or plastic closure. Spring-loaded silos (SLS) or preformed silos have been used as both a salvage technique in patients failing primary closure or as an initial therapy to provide intestinal coverage with definitive closure at a later time. Placement of a SLS has the theoretical benefit of allowing the bowel edema to resolve, allowing partial reduction of the intestine and reduce intraabdominal pressures at the time of definitive fascial closure. Improves splanchnic perfusion resulting in the faster return of bowel function and reduced rates of infection and necrotizing enterocolitis. GS is associated with abnormal intestinal motility and nutrient absorption, both of which gradually improve in most patients. Introduction of enteral feeding is often delayed for weeks while awaiting return of bowel function. During this waiting period, nasogastric decompression and parenteral nutrition are required. When bowel activity occurs, enteral feeds can be started and slowly advanced. Early oral stimulation is recommended to prevent loss of sucking reflex. The presence of complex disease is the most important prognostic determinant for a poor outcome.
Keywords
gastoshiza
kirurške tehnike
silikonska vrećica
ishrana
Keywords (english)
gastroschisis
surgical techniques
a silo
nutrition
Language croatian
URN:NBN urn:nbn:hr:184:613851
Study programme Title: Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resource Text
File origin Born digital
Access conditions Access restricted to students and staff of home institution
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Created on 2018-12-06 15:56:48