prikaz prve stranice dokumenta Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
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Scientific paper - Original scientific paper
Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
Frontiers in Microbiology, 10 (2019); 185. https://doi.org/10.3389/fmicb.2019.00185
Stojanović, Bojana; Milovanović, Jelena; Arsenijević, Aleksandar; Stojanović, Bojan; Stražić Geljić, Ivana; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.; Milovanović, Marija

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Stojanović, B., Milovanović, J., Arsenijević, A., Stojanović, B., Stražić Geljić, I., Arsenijević, N. ... Milovanović, M. (2019). Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Frontiers in Microbiology, 10.. doi: 10.3389/fmicb.2019.00185

Stojanović, Bojana, et al. "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection." Frontiers in Microbiology, vol. 10, 2019. https://doi.org/10.3389/fmicb.2019.00185

Stojanović, Bojana, Jelena Milovanović, Aleksandar Arsenijević, Bojan Stojanović, Ivana Stražić Geljić, Nebojša Arsenijević, Stipan Jonjić, Miodrag L. Lukić and Marija Milovanović. "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection." Frontiers in Microbiology 10 (2019). https://doi.org/10.3389/fmicb.2019.00185

Stojanović, B., et al. (2019) 'Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection', Frontiers in Microbiology, 10. doi: 10.3389/fmicb.2019.00185

Stojanović B, Milovanović J, Arsenijević A, Stojanović B, Stražić Geljić I, Arsenijević N, and sur.. Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Frontiers in Microbiology [Internet]. 2019 February 08 [cited 2024 November 27];10. doi: 10.3389/fmicb.2019.00185

B. Stojanović, et al., "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection", Frontiers in Microbiology, vol. 10, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:088987. [Accessed: 27 November 2024]

Metadata
Title (english)Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
AuthorBojana Stojanović
AuthorJelena Milovanović
AuthorAleksandar Arsenijević
AuthorBojan Stojanović
AuthorIvana Stražić Geljić
AuthorNebojša Arsenijević
AuthorStipan Jonjić
AuthorMiodrag L. Lukić
AuthorMarija Milovanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Galectin-3 (Gal-3) has a role in multiple inflammatory pathways. Various, opposite roles of Gal-3 in liver diseases have been described but there are no data about the role of Gal-3 in development of hepatitis induced with cytomegalovirus infection. In this study we aimed to clarify the role of Gal-3 in murine cytomegalovirus (MCMV)-induced hepatitis by using Gal-3-deficient (Gal-3 KO) mice. Here we provide the evidence that Gal-3 has the protective role in MCMV-induced hepatitis. Enhanced hepatitis manifested by more inflammatory and necrotic foci and serum level of ALT, enhanced apoptosis and necroptosis of hepatocytes and enhanced viral replication were detected in MCMV-infected Gal-3 deficient mice. NK cells does not contribute to more severe liver damage in MCMV-infected Gal-3 KO mice. Enhanced expression of TNF-α in the hepatocytes of Gal-3 KO mice after MCMV infection, abrogated hepatocyte death, and attenuated inflammation in the livers of Gal-3 KO mice after TNF-α blockade suggest that TNF-α plays the role in enhanced disease in Gal-3 deficient animals. Treatment with recombinant Gal-3 reduces inflammation and especially necrosis of hepatocytes in the livers of MCMV-infected Gal-3 KO mice. Our data highlight the protective role of Gal-3 in MCMV-induced hepatitis by attenuation of TNF-α-mediated death of hepatocytes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Microbiology
Numberingvol. 10, 185
e-ISSN1664-302X
DOIhttps://doi.org/10.3389/fmicb.2019.00185
URN:NBNurn:nbn:hr:184:088987
Publication2019-02-08
Document URLhttps://www.frontiersin.org/article/10.3389/fmicb.2019.00185/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2019-03-05 14:28:04