prikaz prve stranice dokumenta MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation
  Download
PDF 653.9 KB
Scientific paper - Original scientific paper
MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation
Journal of Immunology, 138 (1987), 6; 1852-1857. urn:nbn:hr:184:924665
Saalmüller, Armin; Jonjić, Stipan; Bühring, Hans-Jörg; Reddehase, Matthias J.; Koszinowski, Ulrich H.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Saalmüller, A., Jonjić, S., Bühring, H. J., Reddehase, M. J. & Koszinowski, U. H. (1987). MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation. Journal of Immunology, 138. (6), 1852-1857. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:924665

Saalmüller, Armin, et al. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation." Journal of Immunology, vol. 138, no. 6, 1987, pp. 1852-1857. https://urn.nsk.hr/urn:nbn:hr:184:924665

Saalmüller, Armin, Stipan Jonjić, Hans Jörg Bühring, Matthias J. Reddehase and Ulrich H. Koszinowski. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation." Journal of Immunology 138, no. 6 (1987): 1852-1857. https://urn.nsk.hr/urn:nbn:hr:184:924665

Saalmüller, A., et al. (1987) 'MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation', Journal of Immunology, 138(6), pp. 1852-1857. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665 (Accessed 26 November 2024)

Saalmüller A, Jonjić S, Bühring HJ, Reddehase MJ, Koszinowski UH. MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation. Journal of Immunology [Internet]. 1987 [cited 2024 November 26];138(6):1852-1857. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665

A. Saalmüller, S. Jonjić, H. J. Bühring, M. J. Reddehase and U. H. Koszinowski, "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation", Journal of Immunology, vol. 138, no. 6, pp. 1852-1857, 1987. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665. [Accessed: 26 November 2024]

Metadata
Title (english)MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation
AuthorArmin Saalmüller
AuthorStipan Jonjić
AuthorHans-Jörg Bühring
AuthorMatthias J. Reddehase
AuthorUlrich H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence. mAb 8/1 reacts with greater than 95% of thymocytes and in peripheral blood with all T lymphocytes and with cells of the monocyte/macrophage lineage, but not with B cells, erythrocytes, and platelets. Pretreatment of peripheral blood lymphocytes with mAb 8/1 plus complement abrogated the proliferative response in vitro to mitogen, soluble antigen, and MHC determinants. Dual-parameter immunofluorescence revealed that resting porcine T8+ as well as T4+ lymphocytes express the 8/1 antigen, whereas after in vitro activation, cell surface expression of the antigen was low or absent in both T cell subsets. Thus, the 8/1 antigen represents a marker that discriminates between resting and activated T lymphocytes. Distribution and functional criteria indicate that 8/1 represents a novel marker not described before for any other mammalian species.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Immunology
Numberingvol. 138, no. 6, pp. 1852-1857
p-ISSN0022-1767
e-ISSN1550-6606
URN:NBNurn:nbn:hr:184:924665
Publication1987
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2019-04-08 13:59:18