prikaz prve stranice dokumenta Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
No public access
Scientific paper - Original scientific paper
Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
Histology and Histopathology, 26 (2011), 2; 233-245. urn:nbn:hr:184:883327
Jakovac, Hrvoje; Grebić, Damir; Tota, Marin; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Jakovac, H., Grebić, D., Tota, M., Barac Latas, V., Mrakovčić Šutić, I., Milin, Č. & Radošević Stašić, B. (2011). Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats. Histology and Histopathology, 26. (2), 233-245. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, Hrvoje, et al. "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats." Histology and Histopathology, vol. 26, no. 2, 2011, pp. 233-245. https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, Hrvoje, Damir Grebić, Marin Tota, Vesna Barac Latas, Ines Mrakovčić Šutić, Čedomila Milin and Biserka Radošević Stašić. "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats." Histology and Histopathology 26, no. 2 (2011): 233-245. https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, H., et al. (2011) 'Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats', Histology and Histopathology, 26(2), pp. 233-245. Available at: https://urn.nsk.hr/urn:nbn:hr:184:883327 (Accessed 23 November 2024)

Jakovac H, Grebić D, Tota M, Barac Latas V, Mrakovčić Šutić I, Milin Č, and sur.. Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats. Histology and Histopathology [Internet]. 2011 [cited 2024 November 23];26(2):233-245. Available at: https://urn.nsk.hr/urn:nbn:hr:184:883327

H. Jakovac, et al., "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats", Histology and Histopathology, vol. 26, no. 2, pp. 233-245, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:883327. [Accessed: 23 November 2024]

Metadata
Title (english)Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
AuthorHrvoje Jakovac
AuthorDamir Grebić
AuthorMarin Tota
AuthorVesna Barac-Latas
AuthorInes Mrakovčić-Šutić
AuthorČedomila Milin
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
To elucidate the role of metallothioneins (MTs) in the pathomechanisms of autoimmune CNS disorders we estimated the expression of MTs I+II and the tissue concentrations of Zn2+ and Cu2+ in the brain, spinal cord (SC) and in the liver during the periods of attacks and remissions in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE). Disease was induced in the genetically susceptible Dark Agouti (DA) rats by subcutaneous injection of bovine brain homogenate in CFA. Control rats were treated with CFA or with saline solution. The data, obtained by clinical assessment, immunohistochemistry and inductivity coupled plasma spectrometry, have shown that during the first attack (12th day) MTs I+II were markedly upregulated in subarachnoid regions and perivascular space on astrocytes, microglia and spinal neurons. Simultaneously, increased the concentration of zinc in the SC and zinc and copper in the liver. During the second attack (22nd day) a new overexpression of MTs was found in the cerebellum, in sulcus hippocampi, in spinal neurons and particularly on hepatocytes around the central vein. Concomitantly, in the brain and SC increased the concentration of copper. The data point to neuroprotective role of MTs and to important regulatory role of essential metals and hepatic MTs in the pathogenesis of CR-EAE
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHistology and Histopathology
Numberingvol. 26, no. 2, pp. 233-245
p-ISSN0213-3911
URN:NBNurn:nbn:hr:184:883327
Publication2011
ProjectNumber: 062-0621341-1337
Title (croatian): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Leader: Biserka Radošević-Stašić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/442423
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2019-04-14 21:42:04