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Scientific paper - Original scientific paper
Age Dependent Activity of Brush-border Enzymes in BALB/c Mice
Croatica Chemica Acta, 78 (2005), 3; 379-384. urn:nbn:hr:184:101222
Varljen, Jadranka; Detel, Dijana; Batičić, Lara; Eraković, Vesna; Štrbo, Nataša; Ćuk, Mira; Milin, Čedomila

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Varljen, J., Detel, D., Batičić, L., Eraković, V., Štrbo, N., Ćuk, M. & Milin, Č. (2005). Age Dependent Activity of Brush-border Enzymes in BALB/c Mice. Croatica Chemica Acta, 78. (3), 379-384. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:101222

Varljen, Jadranka, et al. "Age Dependent Activity of Brush-border Enzymes in BALB/c Mice." Croatica Chemica Acta, vol. 78, no. 3, 2005, pp. 379-384. https://urn.nsk.hr/urn:nbn:hr:184:101222

Varljen, Jadranka, Dijana Detel, Lara Batičić, Vesna Eraković, Nataša Štrbo, Mira Ćuk and Čedomila Milin. "Age Dependent Activity of Brush-border Enzymes in BALB/c Mice." Croatica Chemica Acta 78, no. 3 (2005): 379-384. https://urn.nsk.hr/urn:nbn:hr:184:101222

Varljen, J., et al. (2005) 'Age Dependent Activity of Brush-border Enzymes in BALB/c Mice', Croatica Chemica Acta, 78(3), pp. 379-384. Available at: https://urn.nsk.hr/urn:nbn:hr:184:101222 (Accessed 14 May 2024)

Varljen J, Detel D, Batičić L, Eraković V, Štrbo N, Ćuk M, and sur.. Age Dependent Activity of Brush-border Enzymes in BALB/c Mice. Croatica Chemica Acta [Internet]. 2005 [cited 2024 May 14];78(3):379-384. Available at: https://urn.nsk.hr/urn:nbn:hr:184:101222

J. Varljen, et al., "Age Dependent Activity of Brush-border Enzymes in BALB/c Mice", Croatica Chemica Acta, vol. 78, no. 3, pp. 379-384, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:101222. [Accessed: 14 May 2024]

Metadata
Title (english)Age Dependent Activity of Brush-border Enzymes in BALB/c Mice
Title (croatian)Utjecaj starenja na aktivnost enzima sluznice tankoga crijeva u BALB/c miševa
AuthorJadranka Varljen
AuthorDijana Detel
AuthorLara Batičić
AuthorVesna Eraković
AuthorNataša Štrbo
AuthorMira Ćuk
AuthorČedomila Milin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Intestinal lactase-phlorizin hydrolase, sucrase-isomaltase and maltase-glucoamylase are brushborder hydrolases important for the digestion of carbohydrates. Alkaline phosphatase is generally used as a marker of epithelial cell maturation. Expression of these enzymes during postnatal development has been characterized, but the effect of ageing on disaccharidase activity is still poorly understood. The aim of this study was to determine the effect of ageing on disaccharidase and alkaline phosphatase activities. Age related changes in 3-, 6- and 12-month-old BALB/c mice were studied. The results of this study showed a statistically significant decrease in all studied enzyme activities, proportional to ageing (P<0.05). Horizontal patterns of disaccharidase and alkaline phosphatase activities were not affected by age. The age related decline in studied enzymes in BALB/c mice could be associated with reduced nutrient absorption and increased incidence of malnutrition in elderly mice. Hence, dietary regulation may be useful for appropriate intestinal absorption with ageing.
Abstract (croatian)
Crijevna laktaza-florizin hidrolaza, saharaza-izomaltaza i maltaza-glukoamilaza su hidrolaze sluznice tankoga crijeva važne za probavu ugljikohidrata. Alkalna fosfataza rabi se kao pokazatelj sazrijevanja epitelnih stanica. Poznat je izražaj navedenih enzima tijekom postnatalnoga razvoja, međutim, još nije dovoljno istražen utjecaj starenja na aktivnost disaharidaza. Cilj ovog istraživanja bio je utvrditi utjecaj starenja na aktivnost disaharidaza i alkalne fosfataze. Proučavane su promjene vezane za starenje u 3, 6 i 12 mjeseci starih BALB/c miševa. Rezultati ovoga istraživanja ukazuju na značajno sniženje aktivnosti istraživanih enzima (P<0,05), proporcionalno sa starenjem. Starenje nije utjecalo na horizontalnu distribuciju aktivnosti disaharidaza i alkalne fosfataze. Sniženje aktivnosti istraživanih enzima tijekom starenja može se povezati sa smanjenom apsorpcijom hranjivih sastojaka te povećanom učestalošću pothranjenosti starijih miševa. Dobiveni rezultati ukazuju na potrebu prilagodbe prehrane, u svrhu regulacije apsorpcije nutrijenata kod starijih populacija.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 78, no. 3, pp. 379-384
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:184:101222
Publication2005
Document URLhttps://hrcak.srce.hr/46
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-04-15 06:36:31