prikaz prve stranice dokumenta Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
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Scientific paper - Original scientific paper
Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
Annals of Translational Medicine, 7 (2019), 16; 374. https://doi.org/10.21037/atm.2019.07.49
Peršić, Viktor; Raljević, Damir; Markova-Car, Elitza; Cindrić, Leon; Miškulin, Rajko; Žuvić, Marta; Pavelić, Sandra Kraljević

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Peršić, V., Raljević, D., Markova Car, E., Cindrić, L., Miškulin, R., Žuvić, M. & Pavelić, S. K. (2019). Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients. Annals of Translational Medicine, 7. (16), 374. doi: 10.21037/atm.2019.07.49

Peršić, Viktor, et al. "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients." Annals of Translational Medicine, vol. 7, no. 16, 2019, p. 374. https://doi.org/10.21037/atm.2019.07.49

Peršić, Viktor, Damir Raljević, Elitza Markova Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić and Sandra Kraljević Pavelić. "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients." Annals of Translational Medicine 7, no. 16 (2019): 374. https://doi.org/10.21037/atm.2019.07.49

Peršić, V., et al. (2019) 'Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients', Annals of Translational Medicine, 7(16), p. 374. doi: 10.21037/atm.2019.07.49

Peršić V, Raljević D, Markova Car E, Cindrić L, Miškulin R, Žuvić M, and sur.. Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients. Annals of Translational Medicine [Internet]. 2019 August [cited 2024 May 05];7(16):374. doi: 10.21037/atm.2019.07.49

V. Peršić, et al., "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients", Annals of Translational Medicine, vol. 7, no. 16, p. 374, August 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867278. [Accessed: 05 May 2024]

Metadata
Title (english)Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
AuthorViktor Peršić
AuthorDamir Raljević
AuthorElitza Markova-Car
AuthorLeon Cindrić
AuthorRajko Miškulin
AuthorMarta Žuvić
AuthorSandra Kraljević Pavelić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Cardiovascular diseases (CVD) are among leading causes of death worldwide and amongst CVD, coronary artery disease (CAD) accounts for almost half of all cardiovascular deaths as the most common cause of death in the developed world. Vitamin D and the vitamin D-binding protein (VDBP) have been studied as possible CAD pathogenesis factors but literature data provide opposing evidence on their role in CAD. Herein we aimed to present novel evidence on the association of two VDBP polymorphisms (rs4588) and (rs7041) with CAD in patients after acute myocardial infarction and study possible correlations of these polymorphisms with 25-hydroxyvitamin D [25(OH)D] serum levels. Methods: The cross-section genotyping study included 155 subjects with CAD upon acute myocardial infarct and 104 control subjects. All patients and control group were Caucasians of European descent. VDBP polymorphisms (rs4588) and (rs7041) were studied by use of RT-PCR. Liquid chromatography, tandem mass spectrometry (LC-MS/MS) method was used for measurement of vitamin D in the serum. Results: Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found. No correlation of 25(OH)D serum levels with CAD were established but the multivariate logistic regression modelling enabled association of total vitamin D level and VDBP (rs4588) T/T genotype with CAD and anteroseptal myocardial infarction (ASMI) CAD occurrence. Conclusions: Obtained data speak in favor to the VDBP (rs4588) T/T genotype as a susceptibility factor for anteroseptal myocardial infarction where the same genotype showed to be generally more prevalent in smokers
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAnnals of Translational Medicine
Numberingvol. 7, no. 16, p. 374
p-ISSN2305-5839
e-ISSN2305-5847
DOIhttps://doi.org/10.21037/atm.2019.07.49
URN:NBNurn:nbn:hr:184:867278
Publication2019-08
Document URLhttp://atm.amegroups.com/article/view/28032/25135
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2019-11-07 16:16:53