Prostate cancer is the most common malignant disease among men in developed countries and second in mortality. Among older men prostate cancer is one of the leading public health problems. In Croatia, it is second most frequent cancer with incidence of 18% and the second cause of the death of the male population suffering from cancer. In most cases, patients are not aware they have cancer because they have no symptoms. Diagnostic methods that have led to more frequent detection of cancer include: prostate specific antigen in serum, digitorectal screening and transrectal ultrasound-guided prostate biopsy. Biopsy is the best method, as it detects cancer differentiation and the extent of the disease's spread. In the treatment of localized cancer, conservative methods and operative procedures, or radical prostatectomy, come into consideration. Conservative methods include active monitoring, hormone therapy and radiotherapy. Despite the opportunities provided, radical prostatectomy continues to be considered the golden standard for prostate cancer treatment. During surgery, prostate, seminal vesicles and lymph nodes are removed. Although results in disease control are better than in conservative methods, incontinence and impotence are often specific complications. Therefore, an important improvement is prostatectomy with the preservation of the neurovascular bundle thereby removing the tumor and maintaining the neurovascular bundle. Laparoscopic and robotic radical prostatectomy are minimally invasive methods that reduce blood loss, postoperative recovery, pain and scar. The percentage of complications is greatest in laparoscopic and the smallest in robotic laparoscopic prostatectomy. Longer time is needed to overcome laparoscopic technique, but it is better for patients, and the results are similar to of classic approach.