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Scientific paper - Original scientific paper
The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells
PLOS Pathogens, 11 (2015), 12; e1005208. https://doi.org/10.1371/journal.ppat.1005208
Ožanič, Mateja; Marečić, Valentina; Abu Kwaik, Yousef; Šantić, Marina

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Ožanič, M., Marečić, V., Abu Kwaik, Y. & Šantić, M. (2015). The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells. PLOS Pathogens, 11. (12). doi: 10.1371/journal.ppat.1005208

Ožanič, Mateja, et al. "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells." PLOS Pathogens, vol. 11, no. 12, 2015. https://doi.org/10.1371/journal.ppat.1005208

Ožanič, Mateja, Valentina Marečić, Yousef Abu Kwaik and Marina Šantić. "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells." PLOS Pathogens 11, no. 12 (2015). https://doi.org/10.1371/journal.ppat.1005208

Ožanič, M., et al. (2015) 'The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells', PLOS Pathogens, 11(12). doi: 10.1371/journal.ppat.1005208

Ožanič M, Marečić V, Abu Kwaik Y, Šantić M. The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells. PLOS Pathogens [Internet]. 2015 December [cited 2024 April 28];11(12). doi: 10.1371/journal.ppat.1005208

M. Ožanič, V. Marečić, Y. Abu Kwaik and M. Šantić, "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells", PLOS Pathogens, vol. 11, no. 12, December 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:983258. [Accessed: 28 April 2024]

Metadata
Title (english)The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells
AuthorMateja Ožanič
AuthorValentina Marečić
AuthorYousef Abu Kwaik
AuthorMarina Šantić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Francisella tularensis isagram-negative,facultative, intracellular bacteriumthatsurvives in mammals, arthropods, and amoebae; however, macrophages are considered thekey cellsin pathogenesis oftularemia in mammals. Understanding intracellular traffickingof F.tularensis within various hostcells isindispensable toourunderstanding ofbacterialecology, intracellularadaptationto various hosts’ microenvironments, and subversion of hostcelldefenses. Withinmammalianand arthropod-derivedcells, F.tularensis transiently resides within an acidicvacuole priortoescapingtothecytosol, wherethebacteriareplicate. Incontrast,F.tularensisresidesandreplicateswithinnon-acidified,membrane-boundvacuoleswithinthetrophozoites ofamoebae. The Francisella pathogenicityisland (FPI) genes encode atype VI Secretion System (T6SS), which isindispensable forphagosomal escape of F.tularensis within mammalian andarthropod cellsand for intravacuolar growth within amoeba. In thisreview, we discuss thedivergentF. tularensis intracellular lifestyle indifferent hosts and itsrolein pathogenic evolution and intracellular proliferation within diverse hosts.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS Pathogens
Numberingvol. 11, no. 12, e1005208
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1005208
URN:NBNurn:nbn:hr:184:983258
Publication2015-12
ProjectNumber: 062-0621273-0950
Title (croatian): Francisella tularensis-unutarstanični život i patogeneza tularemije u miša
Leader: Marina Šantić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://dx.plos.org/10.1371/journal.ppat.1005208
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-31 13:01:30