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Scientific paper - Original scientific paper
NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection
The Journal of Immunology, 198 (2017), 4; 1531-1542. https://doi.org/10.4049/jimmunol.1600461
Lenartić, Maja; Jelenčić, Vedrana; Zafirova, Biljana; Ožanič, Mateja; Marečić, Valentina; Jurković, Slaven; Sexl, Veronika; Šantić, Marina; Wensveen, Felix M.; Polić, Bojan

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Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Lenartić, M., Jelenčić, V., Zafirova, B., Ožanič, M., Marečić, V., Jurković, S. ... Polić, B. (2017). NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. The Journal of Immunology, 198. (4), 1531-1542. doi: 10.4049/jimmunol.1600461

Lenartić, Maja, et al. "NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection." The Journal of Immunology, vol. 198, no. 4, 2017, pp. 1531-1542. https://doi.org/10.4049/jimmunol.1600461

Lenartić, Maja, Vedrana Jelenčić, Biljana Zafirova, Mateja Ožanič, Valentina Marečić, Slaven Jurković, Veronika Sexl, Marina Šantić, Felix M. Wensveen and Bojan Polić. "NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection." The Journal of Immunology 198, no. 4 (2017): 1531-1542. https://doi.org/10.4049/jimmunol.1600461

Lenartić, M., et al. (2017) 'NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection', The Journal of Immunology, 198(4), pp. 1531-1542. doi: 10.4049/jimmunol.1600461

Lenartić M, Jelenčić V, Zafirova B, Ožanič M, Marečić V, Jurković S, and sur.. NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. The Journal of Immunology [Internet]. 2017 February 15 [cited 2025 March 28];198(4):1531-1542. doi: 10.4049/jimmunol.1600461

M. Lenartić, et al., "NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection", The Journal of Immunology, vol. 198, no. 4, pp. 1531-1542, February 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:330829. [Accessed: 28 March 2025]

Metadata
Title (english)NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection
AuthorMaja Lenartić
AuthorVedrana Jelenčić
AuthorBiljana Zafirova
AuthorMateja Ožanič
AuthorValentina Marečić
AuthorSlaven Jurković
AuthorVeronika Sexl
AuthorMarina Šantić
AuthorFelix M. Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
NKG2D is a potent activating receptor that is expressed on cytotoxic immune cells such as CD8 T and NK cells, where it promotes cytotoxicity after binding stress ligands on infected or transformed cells. On NK cell precursors NKG2D modulates proliferation and maturation. Previously, we observed that NKG2D deficiency affects peripheral B cell numbers. In this study, we show that NKG2D regulates B1a cell development and function. We find that mice deficient for NKG2D have a strong reduction of... More B1a cell numbers. As a result, NKG2D-deficient mice produce significantly less Ag-specific IgM Abs upon immunization with T cell–independent Ags, and they are more susceptible to Gram-negative sepsis. Klrk1−/− B1a cells are also functionally impaired and they fail to provide protection against Francisella novicida upon adoptive transfer. Using mixed bone marrow chimeric mice, we show that the impact of NKG2D deficiency on B1a cell development is cell intrinsic. No changes in homeostatic turnover and homing of B cells were detectable, limiting the effects of NKG2D to modulation of the hematopoietic development of B1a cells. Using conditional ablation, we demonstrate that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor. Our findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development. The protective effects of this activating receptor therefore reach beyond that of cytotoxic cells, stimulating the immune system to fight bacterial infections by promoting development of innate-like B cells. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleThe Journal of Immunology
Numberingvol. 198, no. 4, pp. 1531-1542
p-ISSN0022-1767
e-ISSN1550-6606
DOIhttps://doi.org/10.4049/jimmunol.1600461
URN:NBNurn:nbn:hr:184:330829
Publication2017-02-15
ProjectNumber: 062-0621261-1271
Title (croatian): Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1600461
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2020-02-02 18:14:21
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