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Scientific paper - Original scientific paper
Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
eLife, 9 (2020); 50803. https://doi.org/10.7554/eLife.50803
Stražić Geljić, Ivana; Kučan Brlić, Paola; Angulo, Guillem; Brizić, Ilija; Lisnić, Berislav; Jenuš, Tina; Juranić Lisnić, Vanda; Pietri, Gian Pietro; Engel, Pablo; Kaynan, Noa; Železnjak, Jelena; Schu, Peter; Mandelboim, Ofer; Krmpotić, Astrid; Angulo, Ana; Jonjić, Stipan; Lenac Roviš, Tihana More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Stražić Geljić, I., Kučan Brlić, P., Angulo, G., Brizić, I., Lisnić, B., Jenuš, T. ... Lenac Roviš, T. (2020). Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion. eLife, 9.. doi: 10.7554/eLife.50803

Stražić Geljić, Ivana, et al. "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion." eLife, vol. 9, 2020. https://doi.org/10.7554/eLife.50803

Stražić Geljić, Ivana, Paola Kučan Brlić, Guillem Angulo, Ilija Brizić, Berislav Lisnić, Tina Jenuš, Vanda Juranić Lisnić, et al. "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion." eLife 9 (2020). https://doi.org/10.7554/eLife.50803

Stražić Geljić, I., et al. (2020) 'Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion', eLife, 9. doi: 10.7554/eLife.50803

Stražić Geljić I, Kučan Brlić P, Angulo G, Brizić I, Lisnić B, Jenuš T, and sur.. Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion. eLife [Internet]. 2020 January 13 [cited 2024 May 13];9. doi: 10.7554/eLife.50803

I. Stražić Geljić, et al., "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion", eLife, vol. 9, January 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:461982. [Accessed: 13 May 2024]

Metadata
Title (english)Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
AuthorIvana Stražić Geljić
AuthorPaola Kučan Brlić
AuthorGuillem Angulo
AuthorIlija Brizić
AuthorBerislav Lisnić
AuthorTina Jenuš
AuthorVanda Juranić Lisnić
AuthorGian Pietro Pietri
AuthorPablo Engel
AuthorNoa Kaynan
AuthorJelena Železnjak
AuthorPeter Schu
AuthorOfer Mandelboim
AuthorAstrid Krmpotić
AuthorAna Angulo
AuthorStipan Jonjić
AuthorTihana Lenac Roviš
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activation and costimulation of the immune cells. We demonstrate that m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracellular protein sorting and packaging. As a consequence of the perturbed AP-1 sorting, m154 promotes lysosomal degradation of several proteins involved in T cell costimulation, thus impairing virus-specific CD8+ T cell response and virus control in vivo. Additionally, we show that HCMV infection similarly interferes with the AP-1 complex. Altogether, we identify the robust mechanism employed by single viral immunomodulatory protein targeting a broad spectrum of cell surface molecules involved in the antiviral immune response.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleeLife
Numberingvol. 9, 50803
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.50803
URN:NBNurn:nbn:hr:184:461982
Publication2020-01-13
ProjectNumber: UIP-2013-11-1533
Title (croatian): Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi
Acronym: PVRreg
Leader: Tihana Lenac Roviš
Jurisdiction: Croatia
Funding stream: UIP
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://elifesciences.org/articles/50803
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-02-19 17:45:02