prikaz prve stranice dokumenta Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?
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Scientific paper - Case study
Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?
Case Reports in Critical Care, 2019 (2019); 2358562. https://doi.org/10.1155/2019/2358562
Tarčuković, Janja; Valenčić, Lara; Polonijo, Željka; Fućak, Ana; Dangubić, Boban; Grubješić, Igor

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Tarčuković, J., Valenčić, L., Polonijo, Ž., Fućak, A., Dangubić, B. & Grubješić, I. (2019). Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?. Case Reports in Critical Care, 2019.. doi: 10.1155/2019/2358562

Tarčuković, Janja, et al. "Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?." Case Reports in Critical Care, vol. 2019, 2019. https://doi.org/10.1155/2019/2358562

Tarčuković, Janja, Lara Valenčić, Željka Polonijo, Ana Fućak, Boban Dangubić and Igor Grubješić. "Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?." Case Reports in Critical Care 2019 (2019). https://doi.org/10.1155/2019/2358562

Tarčuković, J., et al. (2019) 'Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?', Case Reports in Critical Care, 2019. doi: 10.1155/2019/2358562

Tarčuković J, Valenčić L, Polonijo Ž, Fućak A, Dangubić B, Grubješić I. Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?. Case Reports in Critical Care [Internet]. 2019 December 27 [cited 2024 December 27];2019. doi: 10.1155/2019/2358562

J. Tarčuković, L. Valenčić, Ž. Polonijo, A. Fućak, B. Dangubić and I. Grubješić, "Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?", Case Reports in Critical Care, vol. 2019, December 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:295401. [Accessed: 27 December 2024]

Metadata
Title (english)Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?
AuthorJanja Tarčuković
AuthorLara Valenčić
AuthorŽeljka Polonijo
AuthorAna Fućak
AuthorBoban Dangubić
AuthorIgor Grubješić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Tumour lysis syndrome (TLS) is a group of pathophysiological processes caused by rapid degradation of tumour cells with subsequent release of intracellular contents into the extracellular space. It is characterized by the development of systemic metabolic disturbances with or without clinical manifestations. The process usually occurs in highly proliferative, large tumours after induction of cytotoxic therapy. Rarely, however, spontaneous TLS can develop, as well as signs of multiorgan failure triggered by an excessive metabolic load and sterile inflammation. The combination of the aforementioned is thus quite unique. Here, we present a 63-year-old male in which spontaneous TLS was accompanied with acute liver failure and delineated underlying nonHodgkin lymphoma. Initial laboratory findings included hyperkalaemia, hyperphosphataemia, hypocalcaemia, uraemia, and increased creatinine levels indicating the onset of TLS with acute kidney injury. Moreover, the patient showed signs of jaundice, coagulopathy, and hepatic encephalopathy. Development of TLS with multiorgan failure prompted rapid initiation of critical care management, including vigorous intravenous fluid therapy, allopurinol treatment, high flow continuous venovenous haemodiafiltration, and commencement of chemotherapy. The case highlights the possibility of TLS as a differential diagnosis in patients presenting with multiorgan failure and the importance of early detection of this potentially challenging and fatal diagnosis.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCase Reports in Critical Care
Numberingvol. 2019, 2358562
p-ISSN2090-6420
e-ISSN2090-6439
DOIhttps://doi.org/10.1155/2019/2358562
URN:NBNurn:nbn:hr:184:295401
Online first2019-12-27
Document URLhttps://www.hindawi.com/journals/cricc/2019/2358562/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-03-10 13:02:14