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Professional paper - Review paper
Uloga proteina porodice BCL-2 u psorijazi
Liječnički vjesnik, 132 (2010), 1-2; 31-33. urn:nbn:hr:184:601302
Kaštelan, Marija; Prpić Massari, Larisa; Brajac, Ines

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Kaštelan, M., Prpić Massari, L. & Brajac, I. (2010). Uloga proteina porodice BCL-2 u psorijazi. Liječnički vjesnik, 132. (1-2), 31-33. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:601302

Kaštelan, Marija, et al. "Uloga proteina porodice BCL-2 u psorijazi." Liječnički vjesnik, vol. 132, no. 1-2, 2010, pp. 31-33. https://urn.nsk.hr/urn:nbn:hr:184:601302

Kaštelan, Marija, Larisa Prpić Massari and Ines Brajac. "Uloga proteina porodice BCL-2 u psorijazi." Liječnički vjesnik 132, no. 1-2 (2010): 31-33. https://urn.nsk.hr/urn:nbn:hr:184:601302

Kaštelan, M., Prpić Massari, L. and Brajac, I. (2010) 'Uloga proteina porodice BCL-2 u psorijazi', Liječnički vjesnik, 132(1-2), pp. 31-33. Available at: https://urn.nsk.hr/urn:nbn:hr:184:601302 (Accessed 26 April 2024)

Kaštelan M, Prpić Massari L, Brajac I. Uloga proteina porodice BCL-2 u psorijazi. Liječnički vjesnik [Internet]. 2010 [cited 2024 April 26];132(1-2):31-33. Available at: https://urn.nsk.hr/urn:nbn:hr:184:601302

M. Kaštelan, L. Prpić Massari and I. Brajac, "Uloga proteina porodice BCL-2 u psorijazi", Liječnički vjesnik, vol. 132, no. 1-2, pp. 31-33, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:601302. [Accessed: 26 April 2024]

Metadata
Title (croatian)Uloga proteina porodice BCL-2 u psorijazi
Title (english)The Role of BCL-2 Family Proteins in Psoriasis
AuthorMarija Kaštelan
AuthorLarisa Prpić Massari
AuthorInes Brajac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (croatian)
Apoptoza je fiziološki proces programirane smrti stanica odgovoran za održavanje homeostaze u organizmu. U koži se procesom apoptoze nadzire proliferacija i diferencijacija keratinocita te tako održava homeostaza unutar epidermisa. Proces programirane stanične smrti nadziru proteini porodice Bcl-2 uključujući više proapoptotskih (Bax, Bak, Bad) i protuapoptotskih molekula (Bcl-2, Bcl-xl). Danas se smatra da poremećaj procesa apoptoze ima važnu ulogu u razvoju mnogih kožnih bolesti. Psorijaza je kroničnorecidivirajuća upalna bolest kože obilježena poremećajem diferencijacije i proliferacije keratinocita te sniženom apoptozom keratinocita unutar epidermisa. Na temelju dosadašnjih spoznaja o ulozi programirane stanične smrti u nastanku psorijaze, ~ini se da apoptoza ima važnu ulogu u razvoju epidermalne hiperproliferacije psorijatične lezije. Budć}i da proteini porodice Bcl-2 nadziru proces apoptoze, važno je razjasniti njihovu ulogu u patogenezi psorijaze. Naime, uo~ena povećana ekspresija protuapoptotskih, a sniženo izražavanje proapoptotskih molekula porodice Bcl-2 u psorijatičnoj koži upućuju na njihovu važnost u razvoju bolesti.
Abstract (english)
Apoptosis is a physiological process of programmed cell death responsible for homeostasis in the body. In skin, apoptotic process regulates keratinocyte proliferation and differentiation in that way maintaining homeostasis of epidermal compartment. The process of apoptosis is controlled by proteins of the Bcl-2 family, several proapoptotic (Bax, Bak, Bad) and antiapoptotic (Bcl-2, Bcl-xL) proteins. Nowadays, it seems that dysfunctional apoptosis has an important role in the pathogenesis of several skin diseases. Psoriasis is a chronic hypeproliferative inflammatory skin disease characterized by abnormal keratinocyte hyperproliferation and differentiation as well as by decreased keratinocyte apoptosis. Based on recent studies, it is likely that apoptosis has an important role in epidermal hyperproliferation of psoriatic lesion. Having in mind the significance of Bcl-2 family proteins in apoptosis, it is important to elucidate their role in psoriasis pathogenesis. Observed upregulation of antiapoptotic and downregulation of proapoptotic Bcl-2 family molecules in psoriatic skin implies their significance in psoriasis development.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 132, no. 1-2, pp. 31-33
p-ISSN0024-3477
e-ISSN1849-2177
URN:NBNurn:nbn:hr:184:601302
Publication2010
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-03-28 15:03:07