prikaz prve stranice dokumenta The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
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Scientific paper - Original scientific paper
The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
Physiological Research, 69 (2020); 261-274. https://doi.org/10.33549/physiolres.934243
Saračević, Adrea; Medved, Igor; Hrabrić Vlah, Snježana; Kozmar, Ana; Bilić-Zulle, Lidija; Šimundić, Ana-Maria

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Saračević, A., Medved, I., Hrabrić Vlah, S., Kozmar, A., Bilić Zulle, L. & Šimundić, A. M.. The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries. Physiological Research, 69., 261-274. doi: 10.33549/physiolres.934243

Saračević, Adrea, et al. "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries." Physiological Research, vol. 69, pp. 261-274. https://doi.org/10.33549/physiolres.934243

Saračević, Adrea, Igor Medved, Snježana Hrabrić Vlah, Ana Kozmar, Lidija Bilić Zulle and Ana Maria Šimundić. "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries." Physiological Research 69 261-274. https://doi.org/10.33549/physiolres.934243

Saračević, A., et al. 'The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries', Physiological Research, 69, pp. 261-274. doi: 10.33549/physiolres.934243

Saračević A, Medved I, Hrabrić Vlah S, Kozmar A, Bilić Zulle L, Šimundić AM. The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries. Physiological Research [Internet]. [cited 2025 January 13];69:261-274. doi: 10.33549/physiolres.934243

A. Saračević, I. Medved, S. Hrabrić Vlah, A. Kozmar, L. Bilić Zulle and A. M. Šimundić, "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries", Physiological Research, vol. 69, pp. 261-274. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:326197. [Accessed: 13 January 2025]

Metadata
Title (english)The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
AuthorAdrea Saračević
AuthorIgor Medved
AuthorSnježana Hrabrić Vlah
AuthorAna Kozmar
AuthorLidija Bilić-Zulle
AuthorAna-Maria Šimundić
Author's institutionUniversity of Zagreb
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The aim was to investigate: changes of inflammatory, stress and cardiac response in patients undergoing open heart surgeries up to five days after the procedure; the association between inflammatory, stress and cardiac response and whether changes in a certain marker can predict short-term patient outcome. Ninety patients were divided into three groups, 30 participants each (on-pump,off-pump revascularization and valve replacement group). The following markers were measured:complete blood count, CRP, IL-6, IL-10, leptin, resistin, monocyte chemoattractant protein-1 (MCP-1), cortisol, CK and hsTnT in 5 points. Resistin increased in all three groups. Lower IL-10 levels were found after the surgery and higher levels of leptin and MCP-1 in the off pump than in the on-pump group. Off-pump group had higher values of IL-6, IL-10, leptin, resistin and MCP-1 and lower levels of CK and hsTnT 24 after surgery than the on-pump group. We found significant correlation between MCP-1 and resistin. The difference between resistin at time points 2 and 3 significantly predicted transfusion needs; while the difference between CRP and resistin before and at the end of the surgery together with the difference between leukocytes at the end and 24 hours after the surgery predicted the use of inotropic agents/vasopressors. Cardiac surgeries cause an increase of inflammatory, stress and cardiac markers. Only resistin correlated with MCP-1 which confirms the link between resistin secreted form infiltrated macrophages and enhanced release of MCP-1.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewUnknown
Publication versionSubmitted version
Journal titlePhysiological Research
Numberingvol. 69, pp. 261-274
e-ISSN1802-9973
DOIhttps://doi.org/10.33549/physiolres.934243
URN:NBNurn:nbn:hr:184:326197
Accepted2020
Document URLhttps://doi.org/10.33549/physiolres.934243
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-03-31 15:47:26