prikaz prve stranice dokumenta Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
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Scientific paper - Original scientific paper
Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
Indian Journal of Medical Research, 150 (2019), 1; 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17
Šustar, Aleksandra; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Švob Štrac, Dubravka; Pivac, Nela

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Šustar, A., Nikolac Perković, M., Nedić Erjavec, G., Švob Štrac, D. & Pivac, N. (2019). Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease. Indian Journal of Medical Research, 150. (1), 43-49. doi: 10.4103/ijmr.IJMR_1566_17

Šustar, Aleksandra, et al. "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease." Indian Journal of Medical Research, vol. 150, no. 1, 2019, pp. 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17

Šustar, Aleksandra, Matea Nikolac Perković, Gordana Nedić Erjavec, Dubravka Švob Štrac and Nela Pivac. "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease." Indian Journal of Medical Research 150, no. 1 (2019): 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17

Šustar, A., et al. (2019) 'Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease', Indian Journal of Medical Research, 150(1), pp. 43-49. doi: 10.4103/ijmr.IJMR_1566_17

Šustar A, Nikolac Perković M, Nedić Erjavec G, Švob Štrac D, Pivac N. Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease. Indian Journal of Medical Research [Internet]. 2019 [cited 2024 April 26];150(1):43-49. doi: 10.4103/ijmr.IJMR_1566_17

A. Šustar, M. Nikolac Perković, G. Nedić Erjavec, D. Švob Štrac and N. Pivac, "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease", Indian Journal of Medical Research, vol. 150, no. 1, pp. 43-49, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:626644. [Accessed: 26 April 2024]

Metadata
Title (english)Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
AuthorAleksandra Šustar
AuthorMatea Nikolac Perković
AuthorGordana Nedić Erjavec
AuthorDubravka Švob Štrac
AuthorNela Pivac
Author's institutionUniversity of Zagreb
Author's institutionRuđer Bošković Institute
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background & objectives: Brain-derived neurotrophic factor (BDNF) facilitates neuronal survival, differentiation and synaptic connectivity and affects neurotransmission throughout the brain. However, it has also a modulatory role in energy homeostasis, obesity and cardiovascular function. Obesity, high body mass index (BMI) and dyslipidaemia, among other factors, contribute to coronary heart disease (CHD) development. The exact role of BDNF in development of CHD is not well defined. This study was aimed to evaluate if plasma BDNF concentration was associated with CHD in ethnically homogeneous groups of patients and to correlate plasma BDNF levels with known risk factors for CHD. Methods: Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls. Results: Plasma BDNF concentration was significantly (P <0.01) reduced in patients with CHD compared to controls, and it was not influenced by gender, age, smoking or BDNF Val66Met polymorphism. It was considerably correlated with cholesterol (P=0.004), low-density lipoprotein (P=0.006), and diastolic blood pressure (P=0.018) in patients with CHD and with platelet number (P=0.003) in healthy controls. Interpretation & conclusions: The results revealed lower plasma BDNF concentration in patients with CHD, suggesting that decreased plasma BDNF concentration might be associated with CHD pathogenesis. Longitudinal studies with a large sample need to be conducted to confirm these findings.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleIndian Journal of Medical Research
Numberingvol. 150, no. 1, pp. 43-49
p-ISSN0971-5916
DOIhttps://doi.org/10.4103/ijmr.IJMR_1566_17
URN:NBNurn:nbn:hr:184:626644
Publication2019
ProjectNumber: 098-0982522-2455
Title (croatian): Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja
Leader: Nela Pivac
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://www.ijmr.org.in/text.asp?2019/150/1/43/268213
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2020-04-17 16:29:19