prikaz prve stranice dokumenta Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study
  Download
PDF 128.32 KB
Scientific paper - Original scientific paper
Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study
Croatian medical journal, 61 (2020), 4; 338-345. urn:nbn:hr:184:843212
Gašparović Krpina, Milena; Barišić, Anita; Peterlin, Ana; Tul, Nataša; Ostojić, Saša; Peterlin, Borut; Pereza, Nina

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Gašparović Krpina, M., Barišić, A., Peterlin, A., Tul, N., Ostojić, S., Peterlin, B. & Pereza, N. (2020). Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study. Croatian medical journal, 61. (4), 338-345. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:843212

Gašparović Krpina, Milena, et al. "Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study." Croatian medical journal, vol. 61, no. 4, 2020, pp. 338-345. https://urn.nsk.hr/urn:nbn:hr:184:843212

Gašparović Krpina, Milena, Anita Barišić, Ana Peterlin, Nataša Tul, Saša Ostojić, Borut Peterlin and Nina Pereza. "Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study." Croatian medical journal 61, no. 4 (2020): 338-345. https://urn.nsk.hr/urn:nbn:hr:184:843212

Gašparović Krpina, M., et al. (2020) 'Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study', Croatian medical journal, 61(4), pp. 338-345. Available at: https://urn.nsk.hr/urn:nbn:hr:184:843212 (Accessed 04 December 2024)

Gašparović Krpina M, Barišić A, Peterlin A, Tul N, Ostojić S, Peterlin B, and sur.. Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study. Croatian medical journal [Internet]. 2020 [cited 2024 December 04];61(4):338-345. Available at: https://urn.nsk.hr/urn:nbn:hr:184:843212

M. Gašparović Krpina, et al., "Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study", Croatian medical journal, vol. 61, no. 4, pp. 338-345, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:843212. [Accessed: 04 December 2024]

Metadata
Title (english)Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study
AuthorMilena Gašparović Krpina
AuthorAnita Barišić
AuthorAna Peterlin
AuthorNataša Tul
AuthorSaša Ostojić
MBZ: 376772
AuthorBorut Peterlin
AuthorNina Pereza
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Aim To evaluate the association between the FokI (rs2228570), ApaI (rs7975232), Bsml (rs1544410), TaqI (rs731236), and Cdx2 (rs11568820) single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and spontaneous preterm birth (SPTB), as well as their effect on clinical characteristics of women with SPTB and their newborns. Methods This case-control study enrolled women who gave birth at the Department of Obstetrics and Gynecology, University Medical Center Ljubljana between 2010 to 2019. Cases were 118 women with spontaneous initiation of PTB after natural conception and 119 controls with a term singleton delivery after an uncomplicated pregnancy. The molecular analysis of VDR SNPs employed polymerase chain reaction and restriction fragment length polymorphism. Results Patients and controls did not significantly differ in the distribution of genotype or allele SNP frequencies. However, the FokI polymorphism had a significant effect on newborn birth weight in women with SPTB but not in controls (F=5.17, P=0.007, one-way ANOVA with post-hoc Scheffe test), with newborns of FokI TT carriers having the lowest birth weight (P=0.011). No other VDR SNP was associated with any other clinical characteristic of women with SPTB and their newborns. Conclusion The TT genotype of the VDR FokI polymorphism is associated with newborn birth weight in women of European origin with SPTB.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 61, no. 4, pp. 338-345
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:843212
Publication2020
Document URLhttp://bib.irb.hr/1077811
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-09-17 13:51:59