prikaz prve stranice dokumenta Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells
  Download
PDF 15.58 MB
Scientific paper - Original scientific paper
Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells
Frontiers in Microbiology, 11 (2020); 1179. https://doi.org/10.3389/fmicb.2020.01179
Ouwendijk, Werner J. D.; Dekker, Lennard J. M.; van den Ham, Henk-Jan; Lenac Roviš, Tihana; Haefner, Erik S.; Jonjić, Stipan; Haas, Jürgen; Luider, Theo M.; Verjans, Georges M. G. M.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Ouwendijk, W. J. D., Dekker, L. J. M., van den Ham, H. J., Lenac Roviš, T., Haefner, E. S., Jonjić, S. ... Verjans, G. M. G. M. (2020). Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Frontiers in Microbiology, 11.. doi: 10.3389/fmicb.2020.01179

Ouwendijk, Werner J. D., et al. "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells." Frontiers in Microbiology, vol. 11, 2020. https://doi.org/10.3389/fmicb.2020.01179

Ouwendijk, Werner J. D., Lennard J. M. Dekker, Henk Jan van den Ham, Tihana Lenac Roviš, Erik S. Haefner, Stipan Jonjić, Jürgen Haas, Theo M. Luider and Georges M. G. M. Verjans. "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells." Frontiers in Microbiology 11 (2020). https://doi.org/10.3389/fmicb.2020.01179

Ouwendijk, W. J. D., et al. (2020) 'Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells', Frontiers in Microbiology, 11. doi: 10.3389/fmicb.2020.01179

Ouwendijk WJD, Dekker LJM, van den Ham HJ, Lenac Roviš T, Haefner ES, Jonjić S, and sur.. Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Frontiers in Microbiology [Internet]. 2020 May 29 [cited 2024 May 14];11. doi: 10.3389/fmicb.2020.01179

W. J. D. Ouwendijk, et al., "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells", Frontiers in Microbiology, vol. 11, May 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:388402. [Accessed: 14 May 2024]

Metadata
Title (english)Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells
AuthorWerner J. D. Ouwendijk
AuthorLennard J. M. Dekker
AuthorHenk-Jan van den Ham
AuthorTihana Lenac Roviš
AuthorErik S. Haefner
AuthorStipan Jonjić
AuthorJürgen Haas
AuthorTheo M. Luider
AuthorGeorges M. G. M. Verjans
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) are two closely related human alphaherpesviruses that persistently infect most adults worldwide and cause a variety of clinically important diseases. Herpesviruses are extremely well adapted to their hosts and interact broadly with cellular proteins to regulate virus replication and spread. However, it is incompletely understood how HSV-1 and VZV interact with the host proteome during productive infection. This study determined the temporal changes in virus and host protein expression during productive HSV-1 and VZV infection in the same cell type. Results demonstrated the temporally coordinated expression of HSV-1 and VZV proteins in infected cells. Analysis of the host proteomes showed that both viruses affected extracellular matrix composition, transcription, RNA processing and cell division. Moreover, the prominent role of epidermal growth factor receptor (EGFR) signaling during productive HSV-1 and VZV infection was identified. Stimulation and inhibition of EGFR leads to increased and decreased virus replication, respectively. Collectively, the comparative temporal analysis of viral and host proteomes in productively HSV-1 and VZV-infected cells provides a valuable resource for future studies aimed to identify target(s) for antiviral therapy development.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Microbiology
Numberingvol. 11, 1179
e-ISSN1664-302X
DOIhttps://doi.org/10.3389/fmicb.2020.01179
URN:NBNurn:nbn:hr:184:388402
Publication2020-05-29
Document URLhttps://www.frontiersin.org/article/10.3389/fmicb.2020.01179/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-09-17 16:50:53