prikaz prve stranice dokumenta Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
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Scientific paper - Original scientific paper
Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
Proceedings of the National Academy of Sciences, 117 (2020), 23; 12961-12968. https://doi.org/10.1073/pnas.1914667117
Chaudhry, M. Zeeshan; Casalegno-Garduno, Rosaely; Sitnik, Katarzyna M.; Kasmapour, Bahram; Pulm, Ann-Kathrin; Brizić, Ilija; Eiz-Vesper, Britta; Moosmann, Andreas; Jonjić, Stipan; Mocarski, Edward S.; Cicin-Sain, Luka

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Chaudhry, M. Z., Casalegno Garduno, R., Sitnik, K. M., Kasmapour, B., Pulm, A. K., Brizić, I. ... Cicin Sain, L. (2020). Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proceedings of the National Academy of Sciences, 117. (23), 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry, M. Zeeshan, et al. "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells." Proceedings of the National Academy of Sciences, vol. 117, no. 23, 2020, pp. 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M. Zeeshan, Rosaely Casalegno Garduno, Katarzyna M. Sitnik, Bahram Kasmapour, Ann Kathrin Pulm, Ilija Brizić, Britta Eiz Vesper, et al. "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells." Proceedings of the National Academy of Sciences 117, no. 23 (2020): 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M. Z., et al. (2020) 'Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells', Proceedings of the National Academy of Sciences, 117(23), pp. 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry MZ, Casalegno Garduno R, Sitnik KM, Kasmapour B, Pulm AK, Brizić I, and sur.. Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proceedings of the National Academy of Sciences [Internet]. 2020 June 09 [cited 2024 May 14];117(23):12961-12968. doi: 10.1073/pnas.1914667117

M. Z. Chaudhry, et al., "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells", Proceedings of the National Academy of Sciences, vol. 117, no. 23, pp. 12961-12968, June 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:594837. [Accessed: 14 May 2024]

Metadata
Title (english)Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
AuthorM. Zeeshan Chaudhry
AuthorRosaely Casalegno-Garduno
AuthorKatarzyna M. Sitnik
AuthorBahram Kasmapour
AuthorAnn-Kathrin Pulm
AuthorIlija Brizić
AuthorBritta Eiz-Vesper
AuthorAndreas Moosmann
AuthorStipan Jonjić
AuthorEdward S. Mocarski
AuthorLuka Cicin-Sain
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Viral immune evasion is currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting antigen presentation pathways. We evaluated viral interference with the ultimate step in cytotoxic T cell function, the death of infected cells. The viral inhibitor of caspase-8 activation (vICA) conserved in human cytomegalovirus (HCMV) and murine CMV (MCMV) prevents the activation of caspase-8 and proapoptotic signaling. We demonstrate the key role of vICA from either virus, in deflecting antigen-specific CD8 T cell-killing of infected cells. vICA-deficient mutants, lacking either UL36 or M36, exhibit greater susceptibility to CD8 T cell control than mutants lacking the set of immunoevasins known to disrupt antigen presentation via MHC class I. This difference is evident during infection in the natural mouse host infected with MCMV, in settings where virus-specific CD8 T cells are adoptively transferred. Finally, we identify the molecular mechanism through which vICA acts, demonstrating the central contribution of caspase-8 signaling at a point of convergence of death receptor-induced apoptosis and perforin/granzyme-dependent cytotoxicity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 117, no. 23, pp. 12961-12968
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1914667117
URN:NBNurn:nbn:hr:184:594837
Publication2020-06-09
Document URLhttp://www.pnas.org/lookup/doi/10.1073/pnas.1914667117
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-21 12:28:15