prikaz prve stranice dokumenta Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
  Download
PDF 3.53 MB
Scientific paper - Original scientific paper
Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
Microorganisms, 8 (2020), 10; 1531. https://doi.org/10.3390/microorganisms8101531
Kelava, Ina; Mihelčić, Mirna; Ožanič, Mateja; Marečić, Valentina; Knežević, Maša; Ćurlin, Marija; Štifter, Sanja; Sjöstedt, Anders; Šantić, Marina

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Kelava, I., Mihelčić, M., Ožanič, M., Marečić, V., Knežević, M., Ćurlin, M. ... Šantić, M. (2020). Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs. Microorganisms, 8. (10). doi: 10.3390/microorganisms8101531

Kelava, Ina, et al. "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs." Microorganisms, vol. 8, no. 10, 2020. https://doi.org/10.3390/microorganisms8101531

Kelava, Ina, Mirna Mihelčić, Mateja Ožanič, Valentina Marečić, Maša Knežević, Marija Ćurlin, Sanja Štifter, Anders Sjöstedt and Marina Šantić. "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs." Microorganisms 8, no. 10 (2020). https://doi.org/10.3390/microorganisms8101531

Kelava, I., et al. (2020) 'Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs', Microorganisms, 8(10). doi: 10.3390/microorganisms8101531

Kelava I, Mihelčić M, Ožanič M, Marečić V, Knežević M, Ćurlin M, and sur.. Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs. Microorganisms [Internet]. 2020 October 06 [cited 2024 April 26];8(10). doi: 10.3390/microorganisms8101531

I. Kelava, et al., "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs", Microorganisms, vol. 8, no. 10, October 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:669989. [Accessed: 26 April 2024]

Metadata
Title (english)Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
AuthorIna Kelava
AuthorMirna Mihelčić
AuthorMateja Ožanič
AuthorValentina Marečić
AuthorMaša Knežević
AuthorMarija Ćurlin
AuthorSanja Štifter
AuthorAnders Sjöstedt
AuthorMarina Šantić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Francisella tularensis is a highly virulent intracellular pathogen that proliferates within various cell types and can infect a multitude of animal species. Francisella escapes the phagosome rapidly after infection and reaches the host cell cytosol where bacteria undergo extensive replication. Once cytosolic, Francisella becomes a target of an autophagy-mediated process. The mechanisms by which autophagy plays a role in replication of this cytosolic pathogen have not been fully elucidated. In vitro, F. tularensis avoids degradation via autophagy and the autophagy process provides nutrients that support its intracellular replication, but the role of autophagy in vivo is unknown. Here, we investigated the role of autophagy in the pathogenesis of tularemia by using transgenic mice deficient in Atg5 in the myeloid lineage. The infection of Atg5-deficient mice with Francisella tularensis subsp. holarctica live vaccine strain (LVS) resulted in increased survival, significantly reduced bacterial burden in the mouse organs, and less severe histopathological changes in the spleen, liver and lung tissues. The data highlight the contribution of Atg5 in the pathogenesis of tularemia in vivo.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 8, no. 10, 1531
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms8101531
URN:NBNurn:nbn:hr:184:669989
Publication2020-10-06
ProjectNumber: IP-2016-06-9003
Title (croatian): Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije
Acronym: FRANCYCLE
Leader: Marina Šantić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2076-2607/8/10/1531
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-10-12 22:14:06