prikaz prve stranice dokumenta Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury
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Scientific paper - Original scientific paper
Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury
Journal of Neuropathology & Experimental Neurology, 79 (2020), 11; 1163-1182. https://doi.org/10.1093/jnen/nlaa111
Dolenec, Petra; Pilipović, Kristina; Janković, Tamara; Župan, Gordana

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Cite this document

Dolenec, P., Pilipović, K., Janković, T. & Župan, G. (2020). Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury. Journal of Neuropathology & Experimental Neurology, 79. (11), 1163-1182. doi: 10.1093/jnen/nlaa111

Dolenec, Petra, et al. "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury." Journal of Neuropathology & Experimental Neurology, vol. 79, no. 11, 2020, pp. 1163-1182. https://doi.org/10.1093/jnen/nlaa111

Dolenec, Petra, Kristina Pilipović, Tamara Janković and Gordana Župan. "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury." Journal of Neuropathology & Experimental Neurology 79, no. 11 (2020): 1163-1182. https://doi.org/10.1093/jnen/nlaa111

Dolenec, P., et al. (2020) 'Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury', Journal of Neuropathology & Experimental Neurology, 79(11), pp. 1163-1182. doi: 10.1093/jnen/nlaa111

Dolenec P, Pilipović K, Janković T, Župan G. Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury. Journal of Neuropathology & Experimental Neurology [Internet]. 2020 November 01 [cited 2024 November 09];79(11):1163-1182. doi: 10.1093/jnen/nlaa111

P. Dolenec, K. Pilipović, T. Janković and G. Župan, "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury", Journal of Neuropathology & Experimental Neurology, vol. 79, no. 11, pp. 1163-1182, November 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:812626. [Accessed: 09 November 2024]

Metadata
Title (english)Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury
AuthorPetra Dolenec
AuthorKristina Pilipović
AuthorTamara Janković
AuthorGordana Župan
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Abstract We examined damage and repair processes in the rat cerebellum within the first week following moderate traumatic brain injury (TBI) induced by lateral fluid percussion injury (LFPI) over the left parietal cortex. Rats were killed 1, 3, or 7 days after the injury or sham procedure. Fluoro-Jade B staining revealed 2 phases of neurodegenerative changes in the cell bodies and fibers: first, more focal, 1 day after the LFPI, and second, widespread, starting on post-injury day 3. Purkinje cell loss was detected in posterior lobule IX 1 day following LFPI. Apoptosis was observed in the cerebellar cortex, on days 1 and 7 following LFPI, and was not caspase- or apoptosis-inducing factor (AIF)-mediated. AIF immunostaining indicated axonal damage in the cerebellar white matter tracts 3- and 7-days post-injury. Significant astrocytosis and microgliosis were noticed on day 7 following LFPI at the sites of neuronal damage and loss. Immunohistochemical labeling with the presynaptic markers synaptophysin and growth-associated protein-43 revealed synaptic perturbations already on day 1 that were more pronounced at later time points following LFPI. These results provide new insights into pathophysiological alterations in the cerebellum and their mechanisms following cerebral TBI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Neuropathology & Experimental Neurology
Numberingvol. 79, no. 11, pp. 1163-1182
p-ISSN0022-3069
e-ISSN1554-6578
DOIhttps://doi.org/10.1093/jnen/nlaa111
URN:NBNurn:nbn:hr:184:812626
Publication2020-11-01
ProjectNumber: 062-0620529-0519
Title (croatian): Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija
Leader: Gordana Župan
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://academic.oup.com/jnen/article/79/11/1163/5924443
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2020-11-03 13:25:39