In dental medicine, pain is a common companion of dental tissue inflammatory processes after non-surgical and surgical procedures. Within the masticatory system, it is the most commonly associated with the dental tissues, periodontal tissues, mucosa, muscles, and nerves, and is caused by inflammation, infection, or trauma. Most often, it is an acute pain that needs to be controlled to avoid chronic pain. For this purpose, analgesics are primarily used. The choice of analgesics depends on the intensity of the pain or the type of procedure performed, as well as the indications and contraindications of the drug administration. The treatment should always start with lower doses (ibuprofen 200 - 400 mg or paracetamol 500 mg), gradually increasing it to the maximum daily dose level as needed. For pregnant women, children and the elderly, the drug of choice is paracetamol, and in healthy adults, it is ibuprofen. For specific patient groups, dosage adjustments are required. If these analgesics are not effective enough after reaching the maximum daily doses, they can be prescribed in combination with opioids, according to protocol. This is considered effective because these drugs have different mechanisms of action. Analgesia achieved by two or more analgesics is called multimodal analgesia. Analgesics can be taken before or just after the dental procedure to prevent the development or onset of postoperative pain, which is called preemptive or preventive analgesia.