prikaz prve stranice dokumenta Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
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Scientific paper - Original scientific paper
Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
Diagnostic Pathology, 6 (2011), 1; 108. https://doi.org/10.1186/1746-1596-6-108
Dekanić, Andrea; Dobrila Dintinjan, Renata; Budisavljević, Ivana; Pećanić, Sanja; Žuvić Butorac, Marta; Jonjić, Nives

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Dekanić, A., Dobrila Dintinjan, R., Budisavljević, I., Pećanić, S., Žuvić Butorac, M. & Jonjić, N. (2011). Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology, 6. (1). doi: 10.1186/1746-1596-6-108

Dekanić, Andrea, et al. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology, vol. 6, no. 1, 2011. https://doi.org/10.1186/1746-1596-6-108

Dekanić, Andrea, Renata Dobrila Dintinjan, Ivana Budisavljević, Sanja Pećanić, Marta Žuvić Butorac and Nives Jonjić. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology 6, no. 1 (2011). https://doi.org/10.1186/1746-1596-6-108

Dekanić, A., et al. (2011) 'Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification', Diagnostic Pathology, 6(1). doi: 10.1186/1746-1596-6-108

Dekanić A, Dobrila Dintinjan R, Budisavljević I, Pećanić S, Žuvić Butorac M, Jonjić N. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology [Internet]. 2011 [cited 2024 December 24];6(1). doi: 10.1186/1746-1596-6-108

A. Dekanić, R. Dobrila Dintinjan, I. Budisavljević, S. Pećanić, M. Žuvić Butorac and N. Jonjić, "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification", Diagnostic Pathology, vol. 6, no. 1, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:036056. [Accessed: 24 December 2024]

Metadata
Title (english)Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
AuthorAndrea Dekanić
AuthorRenata Dobrila Dintinjan
AuthorIvana Budisavljević
AuthorSanja Pećanić
AuthorMarta Žuvić Butorac
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Background: Prognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status of tumor cells. Methods: Immunohistochemical and FISH analysis was performed on 135 archival formalin fixed and paraffin embedded CRCs. Results: Strong membrane and strong nuclear EGFR staining was detected in 16% and 57% of cases, respectively, and strong cyclin-D1 expression in 57% samples. Gene EGFR amplification was identified in 5.9% and polysomy in 7.4% of cases, while 87% showed no EGFR gene changes. A statistically significant difference was only found between tumor grade and expression of membrane EGFR, while nuclear EGFR and cyclin-D1 expression was not associated with the clinicopathologic characteristics analyzed. Tumor cells displaying gene amplification and strong protein membrane EGFR expression overlapped, while EGFR gene status showed no correlation with nuclear EGFR and cyclin-D1. There was no association between membrane EGFR and cyclin-D1, whereas nuclear EGFR expression was strongly related to cyclin-D1 expression. Conclusions: Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostic Pathology
Numberingvol. 6, no. 1, 108
p-ISSN1746-1596
DOIhttps://doi.org/10.1186/1746-1596-6-108
URN:NBNurn:nbn:hr:184:036056
Publication2011
ProjectNumber: 062-0620095-0082
Title (croatian): REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA
Leader: Nives Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-6-108
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-11-17 23:38:25