Meningococcal sepsis belongs to the group of invasive meningococcal diseases and due to its nature has always caused special caution among clinicians. It requires urgent recognition of symptoms and adequate care, often in intensive care units. It is caused by gram-negative diplococci, Neisseria meningitidis, most often in serogroups A, B, C, X, Y and W135. Due to various virulence factors, meningococcus very successfully overcomes the immune efforts of the host. The disease most commonly affects infants. The clinical presentation at the beginning of the disease is not specific. Hemorrhagic rash once considered a pathognomonic sign, does not develop in nearly a quarter of patients, and may not initially be petechial. Symptoms that suggest the development of sepsis include severe pain in the legs, cold extremities and pale skin. Treatment includes complex medical procedures like antibiotic and supportive therapy. Since the disease can change its character and severity in a short period of time, it is rational to administer an antibiotic (ceftriaxone) even if there is slightest suspicion. Despite the fact that it is a rare disease, due to high mortality, frequency of complications and severity of the consequences in survivors, meningococcal sepsis remains a public health concern. In Croatia primary prevention by active immunization is not carried out routinely, it is not a component of the current vaccination calendar. The aim of this paper is to raise awareness of the fact that meningococcal disease should always be kept in mind in differential diagnostic thinking in case of unclear febrile condition in a child with a poor general condition.