Title DOBROĆUDNI INTRAKRANIJALNI TUMORI Title (english) BENIGN INTRACRANIAL TUMOURS Author Andrea Kos Mentor Darko Ledić (mentor)Committee member Dean Girotto (predsjednik povjerenstva)Committee member Mira Bučuk (član povjerenstva)Committee member Olivio Perković (član povjerenstva)Granter University of Rijeka Defense date and country 2020-07-17, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Tumori su patološke tvorbe nastale nekontroliranom proliferacije abnormalnih stanica čiji rast nadmašuje i nije u skladu s rastom okolnog normalnog tkiva. Benigne tumore karakterizira polagan, ekspanzivan rast, dobra odjeljenost od okolnog tkiva te dobra diferenciranost. Intrakranijalni tumori su heterogne skupina benignih i malignih tumora, a čine oko 3% svih tumora. Simptomi mogu biti opći i specifični, a ovise o lokalizaciji i veličini tumora koja uzrokuje efekt mase. Dijagnoza se postavlja na temelju kliničke slike, kliničkog statusa i slikovne dijagnostike. MRI je metoda izbora. Klasifikacije tumora središnjeg živčanog sustava Svjetske zdravstvene organizacije iz 2016. objedinjuje histološke i molekularne karakteristike tumora pri čemu definira brojene tumorske entitete. Tumori WHO gradusa I imaju karakteristike benignih neoplazmi, a u njih spadaju glijalni i neglijalni entiteti. Meningeomi su najčešći benigni moždani tumori. Potiču iz arahnoideje te se mogu nalaziti na konveksitetu i na bazi lubanje. Brojni su histološki podtipovi meningeoma.
Uz meningeome u neglijalne intrakranijalne tumore spadaju i kraniofaringeomi i adenomi hipofize koji su smješteni u selarnom području. Glijalni tumori uključuju astrocitome i ependimome. Brojne su vrste i neuronalnih i miješanih neuronalno-glijalnih tumor.
Liječenje tumora uključuje kirurško uklanjanje, radioterapiju, kemoterapiju i hormosko liječenje. Terapija je individulana za svakog pojedinog pacijenta s ciljem uklanjanja tumora, produljenja života i očuvanja kvalitete istoga.
Abstract (english) Tumours are pathological masses of abnormal tissue, characterized by a tendency to grow independently and unrestrainedly. Benign tumours have slow growth rate, are well differentiated and circumscribed. Intracranial tumours are a heterogeneous group of benign and malignant tumours and they account for around 3% of all tumours. Symptoms of a brain tumour can be general, caused by the mass effect, or specific to the location. Diagnosis of a brain tumour is based on medical history, physical exam, and imaging with MRI being the best option. The 2016 World Health Organization Classification of Tumours of the Central Nervous System uses molecular parameters in addition to histology to define many tumour entities. WHO grade I tumours have benign characteristics and include glial and non-glial neoplasms. Most common benign brain tumours are meningiomas that arise from the meninges. They can be located on the surface of the brain and the skull base. There are numerous histological variants of meningioma. Other non-glial include craniopharyngiomas and pituitary adenomas, they are situated in sellar region. Glial tumours are ependymal tumours and astrocytomas. There are multiple neuronal and mixed neuronal-glial tumours. Treatment options include surgical resection, radiotherapy, chemotherapy, and hormonal therapy. Therapy is specific for each patient, it’ s aim being removal of tumour, prolonging the life of patients and ensuring the best possible quality of life.
Keywords
benigni intrakranijalni tumori
moždani tumori
Keywords (english)
benign intracranial tumour
brain tumour
Language croatian URN:NBN urn:nbn:hr:184:936581 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2020-11-25 17:09:42
