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master's thesis
ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA
Rijeka: University of Rijeka, Faculty of Medicine, 2020. urn:nbn:hr:184:449560
Kovačević, Mia
University of Rijeka
Faculty of Medicine
Department of Dermatovenerology

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Kovačević, M. (2020). ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:449560

Kovačević, Mia. "ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:449560

Kovačević, Mia. "ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:449560

Kovačević, M. (2020). 'ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 26 April 2024, https://urn.nsk.hr/urn:nbn:hr:184:449560

Kovačević M. ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2020 [cited 2024 April 26] Available at: https://urn.nsk.hr/urn:nbn:hr:184:449560

M. Kovačević, "ACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:184:449560

Metadata
TitleACNE VULGARIS: PATOGENEZA, KLINIČKA SLIKA I SUVREMENA TERAPIJA
AuthorMia Kovačević
MentorLarisa Prpić Massari (mentor)
Committee memberInes Brajac (predsjednik povjerenstva)
Committee memberSandra Peternel (član povjerenstva)
Committee memberTanja Batinac (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Rijeka
Defense date and country2020-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract
Acne vulgaris je kronična upalna bolest multifaktorijalne etilogije koja zahvaća pilosebacealnu jedinicu. Karakteristično razdoblje oboljevanja od akne je adolescencija uz sve češće perzistiranje ili pojavu akne u odrasloj životnoj dobi. Etiopatogenaza akne je kompleksna, uključuje interakciju brojnih endogenih i egzogenih čimbenika, a glavni mehanizmi nastanka podrazumijevaju seboreju, hiperkeratinizaciju, upalu i C. acnes bakteriju. Klinička slika akne može varirati od blage do teške, karakterizira je raznovrsnost lezija koje uključuju komedone, papule, pustule i nodule te ožiljke i dispigmentacije. U terapiji se trenutno najboji učinak postiže izotretinoinom, ali nedostatak su mu ospežne nuspojave. Od 2019. godine u primjeni je novi topički retinoid, trifaroten. Konstantni napori ulažu se u razvoj lijeka visoke učinkovitosti i dobre podnošljivosti. Dugotrajne akne i ožiljci nerijetko imaju negativne psihosocijalne posljedice na osobu te postoji nužda za učinkovitom i pravovremenom terapijom.
Abstract (english)
Acne vulgaris is a chronic, inflammatory disease with a multifactorial etiology which affects the pilosebaceous unit. The characteristic period of the appearance of acne is during adolescence, with the disease persisting and becoming more common in the adult life. Acne have a complex etiopathogenesis which includes interraction of many endogenous and exogenous factors, and the most important mechanisms of acne pathogenesis are seborrhea, hyperkeratinization, inflammation and the C. acnes bacteria. Clinical presentation of acne can vary from a mild to a severe form, and it is characterised by different lesions such as comedones, papules, pustules, nodules, scars and hyperpigmentation. The best effect in the treatment of acne currently has isotretinoine, but its downside are extreme side effects. In 2019 a new topical retinoid, trifarotene, was introduced into the treatment. Constant effort is invested into the research of medication with a high level of effectiveness and good tolerance. Long term acne and scarring often have negative psychosocial consequences for the person experiencing them and an effective treatment is required.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:449560
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-27 08:11:16