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Scientific paper - Review paper
Epigenetički biomarkeri u presađivanju bubrega
Medicina Fluminensis : Medicina Fluminensis, 56 (2020), 4; 475-482. https://doi.org/10.21860/medflum2020_245225
Frančić, Klara; Katalinić, Nataša; Balen, Sanja

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Frančić, K., Katalinić, N. & Balen, S. (2020). Epigenetički biomarkeri u presađivanju bubrega. Medicina Fluminensis : Medicina Fluminensis, 56. (4), 475-482. doi: 10.21860/medflum2020_245225

Frančić, Klara, et al. "Epigenetički biomarkeri u presađivanju bubrega." Medicina Fluminensis : Medicina Fluminensis, vol. 56, no. 4, 2020, pp. 475-482. https://doi.org/10.21860/medflum2020_245225

Frančić, Klara, Nataša Katalinić and Sanja Balen. "Epigenetički biomarkeri u presađivanju bubrega." Medicina Fluminensis : Medicina Fluminensis 56, no. 4 (2020): 475-482. https://doi.org/10.21860/medflum2020_245225

Frančić, K., Katalinić, N. and Balen, S. (2020) 'Epigenetički biomarkeri u presađivanju bubrega', Medicina Fluminensis : Medicina Fluminensis, 56(4), pp. 475-482. doi: 10.21860/medflum2020_245225

Frančić K, Katalinić N, Balen S. Epigenetički biomarkeri u presađivanju bubrega. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2020 [cited 2024 April 27];56(4):475-482. doi: 10.21860/medflum2020_245225

K. Frančić, N. Katalinić and S. Balen, "Epigenetički biomarkeri u presađivanju bubrega", Medicina Fluminensis : Medicina Fluminensis, vol. 56, no. 4, pp. 475-482, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:965424. [Accessed: 27 April 2024]

Metadata
Title (croatian)Epigenetički biomarkeri u presađivanju bubrega
Title (english)Epigenetic biomarkers in kidney transplantation
AuthorKlara Frančić
AuthorNataša Katalinić
AuthorSanja Balen
MBZ: 236875
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (croatian)
Križna proba, koncentracija kreatinina u serumu i procjena glomerularne filtracije, proteinurije te patohistološki nalaz biopsijom dobivenoga tkiva presatka biološki su markeri koji se koriste u transplantacijskoj medicini. Razvoj genetike i novih tehnologija omogućio je otkriće novih biomarkera kao ranih prediktora akutne reakcije odbacivanja, odgođene funkcije presatka, ishemijsko-reperfuzijske ozljede, intersticijske fibroze i atrofije tubula te dugoročnoga preživljavanja presatka. Radi boljega razumijevanja utjecaja okolišnih čimbenika na humani genom i njihove povezanosti s imunosnim odgovorom u presađivanju bubrega, provedena su brojna istraživanja o epigenetičkim mehanizmima. Cilj je rada prikazati potencijalne epigenetičke biomarkere, produkte epigenetičkih mehanizama i njihovu važnost u ishodu presađivanja bubrega.
Abstract (english)
Currently used prognostic biomarkers in kidney transplantation are – crossmatch, serum creatinine concentration and evaluation of glomerular filtration rate, proteinuria and a histopathological analysis of graft biopsy. The development of genetics and new technologies has enabled the discovery of new biomarkers as early predictors of acute rejection response, delayed graft function, ischemia-reperfusion injury, interstitial fibrosis, tubular atrophy and long-term graft survival. Numerous studies have been conducted to examine the influence of environmental factors on human genome and its relation with the immune response in kidney transplantation. The aim of this article is to present potential epigenetic biomarkers – the products of epigenetic mechanisms, and their importance in the outcome of renal transplantation.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 56, no. 4, pp. 475-482
p-ISSN1847-6864
e-ISSN1848-820X
DOIhttps://doi.org/10.21860/medflum2020_245225
URN:NBNurn:nbn:hr:184:965424
Publication2020
Document URLhttps://hrcak.srce.hr/245225
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-12-01 10:31:31