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Scientific paper - Original scientific paper
Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels
Molecules, 25 (2020), 24; 5916. https://doi.org/10.3390/molecules25245916
Peršurić, Željka; Saftić Martinović, Lara; Malenica, Mladenka; Gobin, Ivana; Pedisić, Sandra; Dragović-Uzelac, Verica; Kraljević Pavelić, Sandra

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Peršurić, Ž., Saftić Martinović, L., Malenica, M., Gobin, I., Pedisić, S., Dragović Uzelac, V. & Kraljević Pavelić, S. (2020). Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels. Molecules, 25. (24). doi: 10.3390/molecules25245916

Peršurić, Željka, et al. "Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels." Molecules, vol. 25, no. 24, 2020. https://doi.org/10.3390/molecules25245916

Peršurić, Željka, Lara Saftić Martinović, Mladenka Malenica, Ivana Gobin, Sandra Pedisić, Verica Dragović Uzelac and Sandra Kraljević Pavelić. "Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels." Molecules 25, no. 24 (2020). https://doi.org/10.3390/molecules25245916

Peršurić, Ž., et al. (2020) 'Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels', Molecules, 25(24). doi: 10.3390/molecules25245916

Peršurić Ž, Saftić Martinović L, Malenica M, Gobin I, Pedisić S, Dragović Uzelac V, and sur.. Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels. Molecules [Internet]. 2020 December 14 [cited 2024 November 07];25(24). doi: 10.3390/molecules25245916

Ž. Peršurić, et al., "Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels", Molecules, vol. 25, no. 24, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:947901. [Accessed: 07 November 2024]

Metadata
Title (english)Assessment of the Biological Activity and Phenolic Composition of Ethanol Extracts of Pomegranate (Punica granatum L.) Peels
AuthorŽeljka Peršurić
AuthorLara Saftić Martinović
AuthorMladenka Malenica
AuthorIvana Gobin
AuthorSandra Pedisić
AuthorVerica Dragović-Uzelac
AuthorSandra Kraljević Pavelić
Author's institutionUniversity of Rijeka
Faculty of Health Studies
Author's institutionUniversity of Rijeka
Faculty of Medicine
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Zagreb
Faculty of Food Technology and Biotechnology
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Pomegranate (Punica granatum L.) is a rich source of constituents with confirmed strong biological activities. However, pomegranate peel, which encompasses approximately 30–40% of its weight, is treated as a biological waste. The aim of this paper was to evaluate the potential of pomegranate peel extracts and to propose its functional properties that can be used for development of functional products. Eight ethanol extracts of pomegranate peels (PPEs) were characterized by use of direct infusion quadrupole-time of flight (Q-TOF), and afterwards tested on their antioxidant, antibacterial and antiproliferative activities. Mass spectrometry analysis revealed that the most prevalent compounds in pomegranate peels were punicalagin, granatin and their derivatives. Analysed extracts had high total phenolic contents that ranged from 5766.44 to 10599.43 mg GAE/100 g, and strong antioxidant activity (7551.31–7875.42 and 100.25–176.60 μmol TE/100 g for DPPH and FRAP assays, respectively). The results of biological activity assays showed that all PPEs possessed antibacterial activity, and that S. aureus was the most sensitive specie with minimum inhibitory concentration and minimum bactericidal concentrations ranging from 0.8 to 6.4 mg/mL. Additionally, the analysis of antiproliferative activity revealed high potency of PPEs, as the IC50 values ranged from 0.132 mg/mL to 0.396 mg/mL. Multivariate analysis pointed out the most discriminative metabolites for antioxidant or antiproliferative activity. Overall, the pomegranate peel confirmed to be a highly valuable source of bioactive compounds that could be used to improve the food functional characteristics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecules
Numberingvol. 25, no. 24, 5916
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules25245916
URN:NBNurn:nbn:hr:184:947901
Publication2020-12-14
Document URLhttps://www.mdpi.com/1420-3049/25/24/5916
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-01-04 13:19:39