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Scientific paper - Original scientific paper
Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity
Obesity Medicine, 20 (2020); 100302. https://doi.org/10.1016/j.obmed.2020.100302
Belančić, Andrej

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Belančić, A. (2020). Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity. Obesity Medicine, 20., 100302. doi: 10.1016/j.obmed.2020.100302

Belančić, Andrej. "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity." Obesity Medicine, vol. 20, 2020, pp. 100302. https://doi.org/10.1016/j.obmed.2020.100302

Belančić, Andrej. "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity." Obesity Medicine 20 (2020): 100302. https://doi.org/10.1016/j.obmed.2020.100302

Belančić, A. (2020) 'Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity', Obesity Medicine, 20, pp. 100302. doi: 10.1016/j.obmed.2020.100302

Belančić A. Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity. Obesity Medicine [Internet]. 2020 December [cited 2024 May 23];20:100302. doi: 10.1016/j.obmed.2020.100302

A. Belančić, "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity", Obesity Medicine, vol. 20, pp. 100302, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:776025. [Accessed: 23 May 2024]

Metadata
Title (english)Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity
AuthorAndrej Belančić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The overall intestinal lipopolysaccharide (LPS) composition in the individuals with obesity could be shifted away from immunosilent/immunoinhibitory Bacteroidetes LPS subtypes, in favor of various proinflammatory LPS subtypes due to gut microbiome dysbiosis. What is more, high-fat diet, as well as obesity per se, enhance intestinal permeability through various mechanisms. Latter results in increased paracellular absorption and transcellular (via chylomicrons) transport of endogenous endotoxin in the circulatory system (endotoxemia). In addition, it is known that lipid A initiates a signaling cascade resulting in activation of various proinflammatory pathways and increases oxidative stress upon binding to tool-like receptor 4 (TLR4). Taking everything into consideration, it is very likely that gut microbiome dysbiosis and endotoxemia represent the additional pathophysiological explanation for increased COVID-19 severity in obesity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleObesity Medicine
Numberingvol. 20, p. 100302, 100302
p-ISSN2451-8476
DOIhttps://doi.org/10.1016/j.obmed.2020.100302
URN:NBNurn:nbn:hr:184:776025
Publication2020-12
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2451847620301226
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2021-01-06 19:45:58