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Scientific paper - Original scientific paper
The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
PLOS Pathogens, 12 (2016), 12; e1006057. https://doi.org/10.1371/journal.ppat.1006057
Thiel, Nadine; Keyser, Kirsten A.; Lemmermann, Niels A. W.; Oduro, Jennifer D.; Wagner, Karen; Elsner, Carina; Halenius, Anne; Lenac Roviš, Tihana; Brinkmann, Melanie M.; Jonjić, Stipan; Čičin-Šain, Luka; Messerle, Martin

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Thiel, N., Keyser, K. A., Lemmermann, N. A. W., Oduro, J. D., Wagner, K., Elsner, C. ... Messerle, M. (2016). The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages. PLOS Pathogens, 12. (12). doi: 10.1371/journal.ppat.1006057

Thiel, Nadine, et al. "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages." PLOS Pathogens, vol. 12, no. 12, 2016. https://doi.org/10.1371/journal.ppat.1006057

Thiel, Nadine, Kirsten A. Keyser, Niels A. W. Lemmermann, Jennifer D. Oduro, Karen Wagner, Carina Elsner, Anne Halenius, et al. "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages." PLOS Pathogens 12, no. 12 (2016). https://doi.org/10.1371/journal.ppat.1006057

Thiel, N., et al. (2016) 'The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages', PLOS Pathogens, 12(12). doi: 10.1371/journal.ppat.1006057

Thiel N, Keyser KA, Lemmermann NAW, Oduro JD, Wagner K, Elsner C, and sur.. The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages. PLOS Pathogens [Internet]. 2016 December [cited 2024 May 14];12(12). doi: 10.1371/journal.ppat.1006057

N. Thiel, et al., "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages", PLOS Pathogens, vol. 12, no. 12, December 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:971179. [Accessed: 14 May 2024]

Metadata
Title (english)The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
AuthorNadine Thiel
AuthorKirsten A. Keyser
AuthorNiels A. W. Lemmermann
AuthorJennifer D. Oduro
AuthorKaren Wagner
AuthorCarina Elsner
AuthorAnne Halenius
AuthorTihana Lenac Roviš
AuthorMelanie M. Brinkmann
AuthorStipan Jonjić
AuthorLuka Čičin-Šain
AuthorMartin Messerle
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus (HCMV) is a tenacious pathogen, which can be life-threatening for immunocompromised patients and immunologically immature newborns. The pathogenicity of HCMV is owed to a plethora of immunomodulatory functions that interfere with host defense mechanisms. Such viral functions can teach us about viral pathogenesis mechanisms, and also about the functioning of immune cells. In this study we report that the mouse cytomegalovirus (MCMV)–a close relative of HCMV–influences surface expression of the cellular protein CD45 on macrophages and we identified the viral gene m42 mediating this effect. CD45 has long been known to be essential for the functioning of lymphocytes, however, its role in macrophages is less well understood. Growth analysis of a viral mutant indicated that the m42 gene confers a replication advantage to MCMV in vivo. We found that the m42 protein induces internalization of CD45 from the plasma membrane and degradation in lysosomes—most likely triggered by interaction of m42 with a ubiquitin ligase. In our study we detected a new element in the complex interaction of cytomegaloviruses with host cells, and further investigation into this mechanism may provide us with new insights into the functions of CD45 in myeloid cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS Pathogens
Numberingvol. 12, no. 12, e1006057
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006057
URN:NBNurn:nbn:hr:184:971179
Publication2016-12
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 260934
Title (english): Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection
Acronym: CMVAGSTIMULUS
Jurisdiction: eu
Funding stream: FP7
Document URLhttps://dx.plos.org/10.1371/journal.ppat.1006057
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-01-20 18:31:23