prikaz prve stranice dokumenta Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
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Scientific paper - Original scientific paper
Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
eLife, 10 (2021); https://doi.org/10.7554/eLife.59350
Angulo, Guillem; Železnjak, Jelena; Martínez-Vicente, Pablo; Puñet-Ortiz, Joan; Hengel, Hartmut; Messerle, Martin; Oxenius, Annette; Jonjić, Stipan; Krmpotić, Astrid; Engel, Pablo; Angulo, Ana

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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion | Paper published in journal / Scientific paper - Original scientific paper

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Angulo, G., Železnjak, J., Martínez Vicente, P., Puñet Ortiz, J., Hengel, H., Messerle, M. ... Angulo, A. (2021). Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife, 10.. doi: 10.7554/eLife.59350

Angulo, Guillem, et al. "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife, vol. 10, 2021. https://doi.org/10.7554/eLife.59350

Angulo, Guillem, Jelena Železnjak, Pablo Martínez Vicente, Joan Puñet Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, et al. "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife 10 (2021). https://doi.org/10.7554/eLife.59350

Angulo, G., et al. (2021) 'Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion', eLife, 10. doi: 10.7554/eLife.59350

Angulo G, Železnjak J, Martínez Vicente P, Puñet Ortiz J, Hengel H, Messerle M, and sur.. Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife [Internet]. 2021 January 18 [cited 2024 December 24];10. doi: 10.7554/eLife.59350

G. Angulo, et al., "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion", eLife, vol. 10, January 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:503816. [Accessed: 24 December 2024]

Metadata
Title (english)Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
AuthorGuillem Angulo
AuthorJelena Železnjak
AuthorPablo Martínez-Vicente
AuthorJoan Puñet-Ortiz
AuthorHartmut Hengel
AuthorMartin Messerle
AuthorAnnette Oxenius
AuthorStipan Jonjić
AuthorAstrid Krmpotić
AuthorPablo Engel
AuthorAna Angulo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated during infection of antigen presenting cells by different herpesviruses. We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr-1 physically interacts with ICOSL, impeding its maturation and promoting its lysosomal degradation. This viral protein counteracts T-cell responses, in an ICOS-dependent manner, and limits virus control during the acute MCMV infection. Additionally, we report that blockade of ICOSL in MCMV-infected mice critically regulates the production of MCMV-specific antibodies due to a reduction of T follicular helper and GC B cells. Altogether, these findings reveal a novel mechanism evolved by MCMV to counteract adaptive immune surveillance and demonstrates a role of the ICOS:ICOSL axis in the host defense against herpesviruses.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusAccepted
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleeLife
Numberingvol. 10
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.59350
URN:NBNurn:nbn:hr:184:503816
Publication2021-01-18
Document URLhttps://elifesciences.org/articles/59350
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-01-25 12:45:46