prikaz prve stranice dokumenta Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
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Scientific paper - Original scientific paper
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
Experimental Biology and Medicine, (2020); 1-9. https://doi.org/10.1177/1535370220968752
Kraljević Pavelić, Sandra; Micek, Vedran; Bobinac, Dragica; Bazdulj, Edo; Gianoncelli, Alessandra; Krpan, Dalibor; Žuvić, Marta; Eisenwagen, Sandra; Stambrook, Peter J; Pavelić, Krešimir

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Kraljević Pavelić, S., Micek, V., Bobinac, D., Bazdulj, E., Gianoncelli, A., Krpan, D. ... Pavelić, K. (2020). Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Experimental Biology and Medicine, 1-9. doi: 10.1177/1535370220968752

Kraljević Pavelić, Sandra, et al. "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial." Experimental Biology and Medicine, 2020, pp. 1-9. https://doi.org/10.1177/1535370220968752

Kraljević Pavelić, Sandra, Vedran Micek, Dragica Bobinac, Edo Bazdulj, Alessandra Gianoncelli, Dalibor Krpan, Marta Žuvić, Sandra Eisenwagen, Peter J Stambrook and Krešimir Pavelić. "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial." Experimental Biology and Medicine (2020): 1-9. https://doi.org/10.1177/1535370220968752

Kraljević Pavelić, S., et al. (2020) 'Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial', Experimental Biology and Medicine, pp. 1-9. doi: 10.1177/1535370220968752

Kraljević Pavelić S, Micek V, Bobinac D, Bazdulj E, Gianoncelli A, Krpan D, and sur.. Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Experimental Biology and Medicine [Internet]. 2020 November 12 [cited 2024 April 30];1-9. doi: 10.1177/1535370220968752

S. Kraljević Pavelić, et al., "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial", Experimental Biology and Medicine, pp. 1-9, November 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:843902. [Accessed: 30 April 2024]

Metadata
Title (english)Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
AuthorSandra Kraljević Pavelić
AuthorVedran Micek
AuthorDragica Bobinac
AuthorEdo Bazdulj
AuthorAlessandra Gianoncelli
AuthorDalibor Krpan
AuthorMarta Žuvić
AuthorSandra Eisenwagen
AuthorPeter J Stambrook
AuthorKrešimir Pavelić
Author's institutionUniversity of Pula
Author's institutionUniversity of Rijeka
Faculty of Health Studies
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their anti-fracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleExperimental Biology and Medicine
Numberingvol. 0, pp. 1-9, 153537022096875
p-ISSN1535-3702
e-ISSN1535-3699
DOIhttps://doi.org/10.1177/1535370220968752
URN:NBNurn:nbn:hr:184:843902
Publication2020-11-12
Document URLhttp://journals.sagepub.com/doi/10.1177/1535370220968752
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-01-28 21:40:31