prikaz prve stranice dokumenta Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
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Scientific paper - Original scientific paper
Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
Immunity, 54 (2021); 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020
Tomac, Jelena; Mazor, Marija; Lisnić, Berislav; Golemac, Mijo; Kveštak, Daria; Bralić, Marina; Bilić-Zulle, Lidija; Brinkmann, Melanie M.; Dölken, Lars; Reinert, Line S.; Paludan, Soren R.; Krmpotić, Astrid; Jonjić, Stipan; Juranić Lisnić, Vanda

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Cite this document

Tomac, J., Mazor, M., Lisnić, B., Golemac, M., Kveštak, D., Bralić, M. ... Juranić Lisnić, V. (2021). Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity, 54., 1478-1493. doi: 10.1016/j.immuni.2021.04.020

Tomac, Jelena, et al. "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility." Immunity, vol. 54, 2021, pp. 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020

Tomac, Jelena, Marija Mazor, Berislav Lisnić, Mijo Golemac, Daria Kveštak, Marina Bralić, Lidija Bilić Zulle, et al. "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility." Immunity 54 (2021): 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020

Tomac, J., et al. (2021) 'Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility', Immunity, 54, pp. 1478-1493. doi: 10.1016/j.immuni.2021.04.020

Tomac J, Mazor M, Lisnić B, Golemac M, Kveštak D, Bralić M, and sur.. Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity [Internet]. 2021 May 19 [cited 2024 May 12];54:1478-1493. doi: 10.1016/j.immuni.2021.04.020

J. Tomac, et al., "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility", Immunity, vol. 54, pp. 1478-1493, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:240644. [Accessed: 12 May 2024]

Metadata
Title (english)Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
AuthorJelena Tomac
AuthorMarija Mazor
AuthorBerislav Lisnić
AuthorMijo Golemac
AuthorDaria Kveštak
AuthorMarina Bralić
AuthorLidija Bilić-Zulle
AuthorMelanie M. Brinkmann
AuthorLars Dölken
AuthorLine S. Reinert
AuthorSoren R. Paludan
AuthorAstrid Krmpotić
AuthorStipan Jonjić
AuthorVanda Juranić Lisnić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Even though pregnant mice successfully controlled CMV infection, we observed highly selective, strong infection of corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failure of immune control in CL cells, resulting in progesterone insufficiency and pregnancy loss. An abundance of gap junctions, absence of vasculature, strong type I interferon (IFN) responses, and interaction of innate immune cells fully protected the ovarian follicles from viral infection. Our work provides fundamental insights into the effect of CMV infection on pregnancy loss and mechanisms protecting fertility.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 54, pp. 1478-1493
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2021.04.020
URN:NBNurn:nbn:hr:184:240644
Publication2021-05-19
ProjectNumber: IP-2016-06-5980
Title (croatian): Patogeneza citomegalovirusne infekcije u jajnicima, utjecaj na plodnost i održavanje trudnoće
Title (english): Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance
Acronym: JaPI
Leader: Vanda Juranić Lisnić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.011.1.01.0006
Title (english): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1074761321001825
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2021-05-27 13:18:05