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Professional paper - Review paper
Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface
Medicina Fluminensis, 57 (2021), 2; 171-176. https://doi.org/10.21860/medflum2021_371640
Braut, Tamara; Krstulja, Mira; Marijić, Blažen; Maržić, Diana; Kujundžić, Milodar; Zamolo, Gordana; Vučinić, Damir; Oštarijaš, Eduard

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Braut, T., Krstulja, M., Marijić, B., Maržić, D., Kujundžić, M., Zamolo, G. ... Oštarijaš, E. (2021). Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface. Medicina Fluminensis, 57. (2), 171-176. doi: 10.21860/medflum2021_371640

Braut, Tamara, et al. "Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface." Medicina Fluminensis, vol. 57, no. 2, 2021, pp. 171-176. https://doi.org/10.21860/medflum2021_371640

Braut, Tamara, Mira Krstulja, Blažen Marijić, Diana Maržić, Milodar Kujundžić, Gordana Zamolo, Damir Vučinić and Eduard Oštarijaš. "Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface." Medicina Fluminensis 57, no. 2 (2021): 171-176. https://doi.org/10.21860/medflum2021_371640

Braut, T., et al. (2021) 'Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface', Medicina Fluminensis, 57(2), pp. 171-176. doi: 10.21860/medflum2021_371640

Braut T, Krstulja M, Marijić B, Maržić D, Kujundžić M, Zamolo G, and sur.. Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface. Medicina Fluminensis [Internet]. 2021 June 01 [cited 2024 December 26];57(2):171-176. doi: 10.21860/medflum2021_371640

T. Braut, et al., "Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface", Medicina Fluminensis, vol. 57, no. 2, pp. 171-176, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:660259. [Accessed: 26 December 2024]

Metadata
Title (english)Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface
Title (croatian)Vrh ledene sante: Maligna transformacija ispod površine glasnica otkrivena imunohistokemijskim markerima
AuthorTamara Braut
AuthorMira Krstulja
AuthorBlažen Marijić
AuthorDiana Maržić
AuthorMilodar Kujundžić
AuthorGordana Zamolo
AuthorDamir Vučinić https://orcid.org/0000-0002-5804-0799
AuthorEduard Oštarijaš
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Abstract. Novel molecular techniques including markers of laryngeal carcinogenesis could improve the difficult diagnosis of a wide array of laryngeal polypoid changes. The case reported herein shows that not every clinically diagnosed vocal fold polyp is a benign lesion as mostly considered in the literature. Further assessment including carcinogenesis markers detected a nest of micro-invasive squamous cell carcinoma. Therefore, we recommend biopsy backed up with immunohistochemical analysis whenever there is a suspicious polypoid formation in order to exclude or confirm a malignant transformation because of the possibility of multi-focal growth in the active laryngeal epithelium.
Abstract (croatian)
Sažetak. Nove molekularne tehnike, uključujući markere laringealne karcinogeneze, mogu pridonijeti diferencijalnoj dijagnozi širokog spektra polipoidnih promjena grkljana. Prikazujemo slučaj koji ukazuje na to da nije svaka klinički dijagnosticirana polipoidna lezija glasnica benigna kao što se obično navodi u literaturi jer smo daljnjom imunohistokemijskom obradom otkrili žarište mikroinvazivnog planocelularnog karcinoma. Stoga kod svake polipoidne tvorbe grkljana preporučujemo biopsiju popraćenu imunohistokemijskom analizom markera kako bi se potvrdila ili isključila maligna transformacija zbog poznate sklonosti multifokalnom rastu u aktivnom epitelu grkljana.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis
Numberingvol. 57, no. 2, pp. 171-176
p-ISSN1847-6864
e-ISSN1848-820X
DOIhttps://doi.org/10.21860/medflum2021_371640
URN:NBNurn:nbn:hr:184:660259
Publication2021-06-01
Document URLhttps://hrcak.srce.hr/255655
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-06-01 06:55:33