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master's thesis
Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom
Rijeka: University of Rijeka, Faculty of Medicine, 2021. urn:nbn:hr:184:897552
Stević, Igor
University of Rijeka
Faculty of Medicine
Department of Anaesthesiology,reanimatology and Intensive Care

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Stević, I. (2021). Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:897552

Stević, Igor. "Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:897552

Stević, Igor. "Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:897552

Stević, I. (2021). 'Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 29 April 2024, https://urn.nsk.hr/urn:nbn:hr:184:897552

Stević I. Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 April 29] Available at: https://urn.nsk.hr/urn:nbn:hr:184:897552

I. Stević, "Prevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:897552

Metadata
TitlePrevalencija fenotipova akutnog respiratornog distres sindroma uzrokovanih SARS-COV-2 virusom
Title (english)Prevalence of phenotypes of acute respiratory distress syndrome caused by SARS-COV-2 virus
AuthorIgor Stević
MentorAlen Protić (mentor)
Committee memberIgor Barković (predsjednik povjerenstva)
Committee memberAlan Šustić (član povjerenstva)
Committee memberVlatka Sotošek Tokmadžić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Rijeka
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
U prosincu 2019. godine dolazi do pojave pneumonije nepoznate etiologije u Wuhanu, Hubei provinciji u Kini. Tomografski prikaz pluća na CT uređaju kod Covid-19 oboljelih pacijenata tipično pokazuje bilateralne infiltrate s multiplim opacifikacijama poput zemljanog stakla (eng. ground glass), konsolidacije bez edema, a kod nekih i asimetrične edematozne lezije i atelektaze uz fibrozu. Znanstvenici pokušavaju fenotipizirati ARDS-a u Covid-19 infekciji s obzirom na kliničku sliku, CT prikaz, biokemijske markere i slično kako bi se mogao odrediti onaj fenotip koji sa sobom donosi veći mortalitet i kako bi se moglo kvalitetno pristupiti liječenju svakog pojedinog tipa. Prevalencija od 26,6% pripada drugom fenotipu koji ima povišene faktore koagulacije kao što su D-dimeri, protrombinsko vrijeme i aktivirano tromboplastinsko vrijeme. Pored faktora koagulacije fenotip dva ima i povišene markere disfunkcije organa poput laktata, kreatinina i troponina, ali i markere upale poput interleukina 6. Prevalencija od oko 25% pripada hiperupalnome fenotipu u kojem pronalazimo povišene markere upale, zatajenja organa, faktore koagulacije što posljedično dovodi to povećanog mortaliteta. Prijelaz iz jednog fenotipa u drugi pronalazi se u manje od 10% pacijenata što ukazuje na stabilnost fenotipova. Literatura ukazuje kako se hiperinflamatorni tip ARDS-a uzrokovan Sars-CoV-2 virusom može prepoznati po tri laboratorijska parametra s obzirom na promjenu koncentracije C reaktivnog proteina ili na udvostručenje koncentracije unutar 24 sata te koncentracijom feritina.
Abstract (english)
In December 2019, pneumonia of unknown etiology occurred in Wuhan, Hubei Province, China. CT scan of the lung in Covid-19 patients typically shows bilateral infiltrates with multiple opacifications such as ground glass, consolidation without edema, and in some asymmetric edematous lesions and atelectasis with fibrosis. Scientists are trying to phenotype ARDS in Covid-19 infection with regard to the clinical picture, CT scan, biochemical markers and other differences in order to determine the phenotype that has higher mortality and to be able to create approach to the treatment of each type. The prevalence of 26.6% belongs to another phenotype that has elevated coagulation factors such as D-dimers, prothrombin time, and activated thromboplastin time. In addition to coagulation factors, phenotype two has elevated markers of organ dysfunction such as lactate, creatinine and troponin, but also markers of inflammation such as interleukin 6. The prevalence of about 25% belongs to the hyperinflammatory phenotype in which we find elevated markers of inflammation, organ failure, coagulation factors with increased mortality. Transition from one phenotype to another is found in less than 10% of patients indicating phenotype stability. The literature indicates that the hyperinflammatory type of ARDS caused by Sars-CoV-2 virus can be identified by three laboratory parameters due to the change in the concentration of reactive protein C or the doubling of the concentration within 24 hours and the concentration of ferritin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:897552
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-06-27 11:45:13