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master's thesis
Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza
Rijeka: University of Rijeka, Faculty of Medicine, 2021. urn:nbn:hr:184:583385
Međimurec, Marko
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Međimurec, M. (2021). Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:583385

Međimurec, Marko. "Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:583385

Međimurec, Marko. "Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:583385

Međimurec, M. (2021). 'Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 09 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:583385

Međimurec M. Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 May 09] Available at: https://urn.nsk.hr/urn:nbn:hr:184:583385

M. Međimurec, "Nealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:583385

Metadata
TitleNealkoholna masna bolest jetre i komplikacije šećerne bolesti tipa 2 - retrospektivna analiza
Title (english)Nonalcoholic fatty liver disease and complications of type 2 diabetes mellitus – retrospective analysis
AuthorMarko Međimurec
MentorIvana Mikolašević (mentor)
Committee memberSandra Milić (predsjednik povjerenstva)
Committee memberDražen Kovač (član povjerenstva)
Committee memberVanja Licul (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj: Cilj ove analize bio je utvrditi povezanost parametara steatoze i fibroze (CAP i LSM) pomoću tranzijentne elastografije (Fibroscan®) sa pojavom mikrovaskularnih i makrovaskularnih komplikacija T2DM. Materijali i metode: Istraživanje je provedeno u Kliničkom bolničkom centru Rijeka i Kliničkoj bolnici Merkur, s podatcima dostupnima u razdoblju od siječnja 2015. do studenog 2020. Uključeno je bilo 442 pacijenta s dijagnozom T2DM. Promatrani su parametri steatoze (CAP ≥238 dB/m) i fibroze jetre (LSM ≥7.0/ ≥6.2 kPa za M/XL sondu) te pojava makrovaskularnih (ishemijski moždani udar, infarkt miokarda) i mikrovaskularnih (dijabetička retinopatija, nefropatija i neuropatija) komplikacija T2DM. Rezultati: Trećina pacijenata imalo je prekomjernu tjelesnu težinu, a 55% je bilo pretilo. Srednje trajanje dijabetesa bilo je 10 godine. 72% pacijenata imalo je loše kontroliranu bolesti. Steatoza jetre pronađena je u 84.2% pacijenata sa srednjim vrijednostima CAP-a 317 (266-357) dB/m. Fibroza jetre ponađena je u 46% pacijenata sa srednjim vrijednostima LSM-a 5.4 (4.5-7) kPa. LSM vrijednost bila je neovisno povezana s infarktom miokarda (OR 6.61), neuropatijom (OR 4.55), kroničnom bubrežnom bolesti (OR 4.54), retinopatijom(OR 1.81). Zaključak: U istraživanju smo pokazali da je parametar tvrdoće jetre (LSM) nezavisni prediktivni čimbenik za razvoj mikrovaskularnih i makrovaskularnih komplikacija šećerne bolesti tip 2. Potrebna su daljnja prospektivna istraživanja, koja će pokazati hoće li se u budućnosti tranzijentna elastografija moći koristiti kao marker za detekciju vaskularnih komplikacija T2DM.
Abstract (english)
Aim: The aim of this analysis is to determinate the association of liver steatosis and fibrosis (measured by CAP and LSM) using transient elastography (Fibroscan®) with the occurence of microvascular and macrovascular complications of T2DM. Materials and Methods: The study was conducted at the Clinical Hospital Center Rijeka and the Clinical Hospital Merkur, with data available from January 2015 to November 2020. 442 patients with a diagnosis of T2DM were included. The parameters of liver steatosis (CAP ≥238 dB/m) and liver fibrosis (LSM ≥7.0/ ≥6.2 kPa, M/XL probe) were observed as well as their impact on the occurence of micovascular and macrovascular complications of T2DM. Results: About a third of the patients were overweight and 55% were obese. The median duration of diabetes was 10 years. Poor disease control was found in 72% of the patients. Hepatic steatosis was found in 84.2% of the patients with median CAP values of 317 (266-357) dB/m. Liver fibrosis was found in 46% of te patients with mean LSM values 5.4 (4.5-7) kPa. LSM value was independently associated with miocardial infarction (OR 6.61), neuropathy (OR 4.55), chronic kidney disease (OR 4.54) and retinopathy (OR1.81). Conclusion: In the analysis, we showed that the liver hardness parameter (LSM) is an independent predictive risk factor for the development of macrovascular and microvascular complications of T2DM. Further prospective research is needed, which will show whether transient elastography can be used as a marker to detect vascular complications of T2DM patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:583385
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-07-05 09:31:21