prikaz prve stranice dokumenta Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom
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master's thesis
Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom
Rijeka: University of Rijeka, Faculty of Medicine, 2016. urn:nbn:hr:184:816695
Žutelija, Marta
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Žutelija, M. (2016). Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:816695

Žutelija, Marta. "Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:816695

Žutelija, Marta. "Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:816695

Žutelija, M. (2016). 'Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 07 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:816695

Žutelija M. Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2016 [cited 2024 November 07] Available at: https://urn.nsk.hr/urn:nbn:hr:184:816695

M. Žutelija, "Utjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:184:816695

Metadata
TitleUtjecaj inhibitora renin-angiotenzin-aldosteronskog sustava na krvnu sliku kod bolesnika s bubrežnim transplantatom
AuthorMarta Žutelija
MentorLidija Orlić (mentor)
Committee memberSrđan Novak (predsjednik povjerenstva)
Committee memberGoran Hauser (član povjerenstva)
Committee memberAlemka Brnčić-Fischer (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2016-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
RAAS inhibitori često su korišteni lijekovi kod bolesnika s bubrežnim transplantatom zbog povoljnog antihipertenzivnog i renoprotektivnog učinka, ali postoji oprez oko njihovog korištenja zbog moguće pojave hiperkalijemije, renalne disfunkcije i anemije. Cilj ovog istraživanja bio je procijeniti utjecaj RAAS inhibitora na serumske razine Hb i Htc te na funkciju bubrežnog transplantata kod transplantiranih bolesnika sa stabilnim bubrežnim transplantatom u ovisnosti o početnim višim ili nižim vrijednostima Hb i Htc. U istraživanje je uključeno 270 bolesnika sa stabilnim bubrežnim transplantatom. Osim druge propisane antihipertenzivne terapije 169 bolesnika koristilo je RAAS inhibitore. Kako bi se procijenio utjecaj RAAS inhibitora na Hb i Htc kod bolesnika s početnim nižim ili višim vrijednostima ovih parametara, samo oni koji su uzimali RAAS inhibitore podijeljeni su u dvije skupine: jednu s višim vrijednostima Hb i Htc (početne vrijednosti Hb ≥150 g/L i Htc ≥45%) i drugu s nižim vrijednostima Hb i Htc (početne vrijednosti Hb ≤150 g/L i Htc ≤45%). Kod bolesnika s početnim višim vrijednostima Hb i Htc došlo je do značajnog pada u vrijednostima Hb i Htc, a u grupi bolesnika s početnim nižim vrijednostima Hb i Htc došlo je do značajnog porasta u vrijednostima Hb i Htc nakon dvanaestomjesečnog perioda praćenja. Korištenje RAAS inhibitora bilo je povezano s trendom usporavanja insuficijencije bubrežnog transplantata. Na temelju rezultata zaključuje se da RAAS inhibitori snižavaju razinu Hb i Htc samo kod transplantiranih bolesnika s početnim višim vrijednostima, a kod onih s početnim nižim vrijednostima imaju povoljan utjecaj na eritropoezu i funkciju bubrežnog presatka.
Abstract (english)
RAAS inhibitors are often prescribed medications in the kidney transplant population due to their beneficial antihypertensive and renoprotective effects, but there is the caution about their usage because of possible hyperkalemia, renal dysfunction and anemia. The aim of this study was to evaluate the effect of RAAS inhibitors on serum Hb and Htc and renal graft function in stable renal transplant recipients in respect with initially higher or lower Hb and Htc values. In this study 270 stable renal transplant recipients have been evaluated. Besides other prescribed antihypertensive therapy, 169 of them have been taking RAAS inhibitors. To evaluate the effect of RAAS inhibitors on Hb and Htc in patients with initially higher or lower levels of these parameters, only those who have been taking RAAS inhibitors were stratified into two groups: one with higher Hb and Htc (initial Hb ≥ 150 g/L and Htc ≥ 45%) and another one with lower Hb and Htc (initial Hb b 150 g/L and Htc b 45%) values. Patients with initially higher Hb and Htc had a significant decrease in Hb and Htc and those with initially lower Hb and Htc had a significant increase in Hb and Htc levels after 12-months of follow-up. The use of RAAS inhibitors has been associated with a trend of slowing renal insufficiency. In conclusion, RAAS inhibitors lower Hb and Htc only in those renal transplant recipients with initially higher levels. In those with initially lower levels they have beneficial impact on erythropoiesis and kidney graft function.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:816695
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-10-11 12:35:51