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Scientific paper - Original scientific paper
Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression
Acta clinica Croatica, 60. (2021), Supplement 1; 114-117. https://doi.org/10.20471/acc.2021.60.s1.16
Prkačin, Ingrid; Findri, Pavao; Novak, Ana Marija; Pleše, Jakov; Bulum, Tomislav; Bubić, Ivan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Prkačin, I., Findri, P., Novak, A. M., Pleše, J., Bulum, T. & Bubić, I. (2021). Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression. Acta clinica Croatica, 60.. (Supplement 1), 114-117. doi: 10.20471/acc.2021.60.s1.16

Prkačin, Ingrid, et al. "Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression." Acta clinica Croatica, vol. 60., no. Supplement 1, 2021, pp. 114-117. https://doi.org/10.20471/acc.2021.60.s1.16

Prkačin, Ingrid, Pavao Findri, Ana Marija Novak, Jakov Pleše, Tomislav Bulum and Ivan Bubić. "Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression." Acta clinica Croatica 60., no. Supplement 1 (2021): 114-117. https://doi.org/10.20471/acc.2021.60.s1.16

Prkačin, I., et al. (2021) 'Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression', Acta clinica Croatica, 60.(Supplement 1), pp. 114-117. doi: 10.20471/acc.2021.60.s1.16

Prkačin I, Findri P, Novak AM, Pleše J, Bulum T, Bubić I. Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression. Acta clinica Croatica [Internet]. 2021 [cited 2024 May 14];60.(Supplement 1):114-117. doi: 10.20471/acc.2021.60.s1.16

I. Prkačin, P. Findri, A. M. Novak, J. Pleše, T. Bulum and I. Bubić, "Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression", Acta clinica Croatica, vol. 60., no. Supplement 1, pp. 114-117, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:707996. [Accessed: 14 May 2024]

Metadata
Title (english)Probiotics and High Fiber-Rich Diets Have Anti-Inflammatory Properties and Decline Chronic Kidney Disease Progression
Title (croatian)Probiotici i dijetalna prehrana bogata vlaknima uz protuupalne učinke usporava i progresiju kronične bubrežne bolesti
AuthorIngrid Prkačin https://orcid.org/0000-0002-5830-7131
AuthorPavao Findri
AuthorAna Marija Novak
AuthorJakov Pleše
AuthorTomislav Bulum
AuthorIvan Bubić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
A well balanced, time-restricted diet with 50% more vegetables and restriction of red meat can delay the progression of kidney damage. This paper suggests that such diet changes can also have an immunoregulatory role, with adding pre/probiotics. There were two groups of patients (20M/28F; age 67±9 years, estimated glomerular filtration rate 42,1±12 ml/min/1.73m2): group A practiced a modified diet that consisted of certain nutritional changes (50% more vegetable intake, reduction of red meat to twice per week), time-restricted eating (8 hours), and taking probiotics. Group B was also taking probiotics; however, their nutrition included no restrictions on red meat intake, they ate fewer vegetables, and there was no time-restricted eating. After 3 months, therapy from Group A − a balanced, time-restricted diet plus probiotics, resulted in weight loss (from 113±13 to 110±18 kg), body mass index decrease (from 36.4±5.1 to 34±5 kg/m2), decrease in waist circumference (from 119±11 to 115±10 cm), as well as lower hsC-reactive protein by 8% (group A) and 5% (group B). The values of kidney function measurements after 3 months were 45,3±11 ml/min/1.73m² in group A, while in group B, those were 42,4±10 ml/min/1.73m² (p<0.05). This study shows a positive correlation between the daily consumption of probiotics and decreased progression of chronic kidney disease.
Abstract (croatian)
Istražili smo učinak dodatka probiotika i njegovu potencijalnu imunoregulatornu ulogu u 48 bolesnika s kroničnom bubrežnom bolesti kroz 3 mjeseca. U prospektivnoj studiji (20M/28F; srednje dobi 67±9 godina, eGFR 42,1±12 mlmin- 11.73m2.) bolesnici su bili podijeljeni u skupinu A s dijetom koja je uključivala smanjeno uzimanje crvenog mesa (samo 2x tjedno), povećan unos povrća na 50%, uz 8-satni vremenski period bez uzimanja hrane i uz dodatak probiotika. Skupina B nije mijenjala postojeće prehrambene navike, međutim uzimala je isti probiotik kao i skupina A. U periodu praćenja nakon 3 mjeseca postignuta je značajno sniženje tlaka, težine i opsega struka u grupi A: BMI s 36.4±5.1 na 34±5 kg/m2, tjelesna težina s 113±13 na 110±18 kg, opseg struka s 119±11 na 115±10 cm, dok u skupini B nisu zabilježene promjene. U obje grupe uočeno je sniženje razine hsCRP-a, i to za 8% u grupi A, odnosno 5% u grupi B. Bubrežna funkcija procijenjena eGFR nakon 3 mjeseca u skupini A iznosila je 45.3±11 ml/min/1.73m², a u grupi B 42.4±10 ml/min/1.73m² (p<0.05). Prehrana sa sniženim unosom proteina životinjskog porijekla, više proteina biljnog porijekla, pridržavanje neuzimanja hrane kroz osam sati i dodatak probiotika, dodatno usporava progresiju kronične bubrežne bolesti i ima protuupalni učinak.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 60., no. Supplement 1, pp. 114-117
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2021.60.s1.16
URN:NBNurn:nbn:hr:184:707996
Publication2021
Document URLhttps://hrcak.srce.hr/260411
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-08-31 10:09:23