prikaz prve stranice dokumenta An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
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Scientific paper - Original scientific paper
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
GERMS, 11 (2021), 2; 199-210. https://doi.org/10.18683/germs.2021.1257
Matovina, Mihaela; Abram, Maja; Repac-Antić, Davorka; Knežević, Samira; Bubonja-Šonje, Marina

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Matovina, M., Abram, M., Repac Antić, D., Knežević, S. & Bubonja Šonje, M. (2021). An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex. GERMS, 11. (2), 199-210. doi: 10.18683/germs.2021.1257

Matovina, Mihaela, et al. "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex." GERMS, vol. 11, no. 2, 2021, pp. 199-210. https://doi.org/10.18683/germs.2021.1257

Matovina, Mihaela, Maja Abram, Davorka Repac Antić, Samira Knežević and Marina Bubonja Šonje. "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex." GERMS 11, no. 2 (2021): 199-210. https://doi.org/10.18683/germs.2021.1257

Matovina, M., et al. (2021) 'An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex', GERMS, 11(2), pp. 199-210. doi: 10.18683/germs.2021.1257

Matovina M, Abram M, Repac Antić D, Knežević S, Bubonja Šonje M. An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex. GERMS [Internet]. 2021 [cited 2024 May 02];11(2):199-210. doi: 10.18683/germs.2021.1257

M. Matovina, M. Abram, D. Repac Antić, S. Knežević and M. Bubonja Šonje, "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex", GERMS, vol. 11, no. 2, pp. 199-210, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:844971. [Accessed: 02 May 2024]

Metadata
Title (english)An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
AuthorMihaela Matovina
MBZ: 254976
AuthorMaja Abram
AuthorDavorka Repac-Antić
AuthorSamira Knežević
AuthorMarina Bubonja-Šonje
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Introduction: Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen with dynamic molecular epidemiology. This study presents a retrospective analysis of the distribution and antibiotic resistance patterns of ertapenem-resistant ESBL-producing K. pneumoniae strains recovered during an outbreak from 2012 to 2014 in a Croatian University hospital. Methods We aimed to estimate genetic relatedness of clinical isolates and underlying mechanisms that conferred the ertapenem- resistant phenotype. Results: Expression analysis of genes involved in the antibiotic resistance showed reduced expression of major non-selective porin channel OmpK35. Reduced expression of OmpK36 porin channel in isolates resistant to at least one more carbapenem, apart from the ertapenem, was found to a lesser degree. Pulsed-field gel electrophoresis analysis of genomic DNA revealed that almost all isolates belonged to the same genetic clone. Conclusions: Caution regarding ertapenem- resistant, carbapenemase-negative porin- deficient mutants of K. pneumoniae is required as they are widespread, and under selective pressure this could result in a local clonal outbreak.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGERMS
Numberingvol. 11, no. 2, pp. 199-210
p-ISSN2248-2997
DOIhttps://doi.org/10.18683/germs.2021.1257
URN:NBNurn:nbn:hr:184:844971
Publication2021
ProjectNumber: uniri-biomed-18-215
Title (croatian): Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B
Title (english): Prevalence and clinical significance of hepatitis B surface antigen mutants
Leader: Marina Bubonja Šonje
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: uniri-biomed-18-277
Title (croatian): Bakterijska patogeneza - od istraživanja do kliničke primjene
Title (english): Bacterial pathogenesis – from research to clinics
Leader: Maja Abram
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1139517
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-09-08 11:29:50