prikaz prve stranice dokumenta The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding
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Scientific paper - Original scientific paper
The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding
Pathogens, 10 (2021), 7; 866. https://doi.org/10.3390/pathogens10070866
Chan, Baca; Arapović, Maja; Masters, Laura L.; Rwandamuiye, Francois; Jonjić, Stipan; Smith, Lee M.; Redwood, Alec J.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Chan, B., Arapović, M., Masters, L. L., Rwandamuiye, F., Jonjić, S., Smith, L. M. & Redwood, A. J. (2021). The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding. Pathogens, 10. (7). doi: 10.3390/pathogens10070866

Chan, Baca, et al. "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding." Pathogens, vol. 10, no. 7, 2021. https://doi.org/10.3390/pathogens10070866

Chan, Baca, Maja Arapović, Laura L. Masters, Francois Rwandamuiye, Stipan Jonjić, Lee M. Smith and Alec J. Redwood. "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding." Pathogens 10, no. 7 (2021). https://doi.org/10.3390/pathogens10070866

Chan, B., et al. (2021) 'The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding', Pathogens, 10(7). doi: 10.3390/pathogens10070866

Chan B, Arapović M, Masters LL, Rwandamuiye F, Jonjić S, Smith LM, and sur.. The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding. Pathogens [Internet]. 2021 July 09 [cited 2024 November 23];10(7). doi: 10.3390/pathogens10070866

B. Chan, et al., "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding", Pathogens, vol. 10, no. 7, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:426058. [Accessed: 23 November 2024]

Metadata
Title (english)The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding
AuthorBaca Chan
AuthorMaja Arapović
AuthorLaura L. Masters
AuthorFrancois Rwandamuiye
AuthorStipan Jonjić
AuthorLee M. Smith
AuthorAlec J. Redwood
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
As the largest herpesviruses, the 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding of host immunity and viral escape mechanisms, although many of the annotated genes remain as yet uncharacterised. Here we identify the m15 locus of murine CMV (MCMV) as a viral modulator of natural killer (NK) cell immunity. We show that, rather than discrete transcripts from the m14, m15 and m16 genes as annotated, there are five 3′-coterminal transcripts expressed over this region, all utilising a consensus polyA tail at the end of the m16 gene. Functional inactivation of any one of these genes had no measurable impact on viral replication. However, disruption of all five transcripts led to significantly attenuated dissemination to, and replication in, the salivary glands of multiple strains of mice, but normal growth during acute infection. Disruption of the m15 locus was associated with heightened NK cell responses, including enhanced proliferation and IFNγ production. Depletion of NK cells, but not T cells, rescued salivary gland replication and viral shedding. These data demonstrate the identification of multiple transcripts expressed by a single locus which modulate, perhaps in a concerted fashion, the function of anti-viral NK cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathogens
Numberingvol. 10, no. 7, 866
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens10070866
URN:NBNurn:nbn:hr:184:426058
Publication2021-07-09
Document URLhttps://www.mdpi.com/2076-0817/10/7/866
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-09-17 12:22:23