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Scientific paper - Original scientific paper
IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
Cancers, 13 (2021), 17; 4306. https://doi.org/10.3390/cancers13174306
Maržić, Diana; Marijić, Blažen; Braut, Tamara; Janik, Stefan; Avirović, Manuela; Hadžisejdić, Ita; Tudor, Filip; Radobuljac, Katarina; Čoklo, Miran; Erovic, Boban M.

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Maržić, D., Marijić, B., Braut, T., Janik, S., Avirović, M., Hadžisejdić, I. ... Erovic, B. M. (2021). IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers, 13. (17). doi: 10.3390/cancers13174306

Maržić, Diana, et al. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers, vol. 13, no. 17, 2021. https://doi.org/10.3390/cancers13174306

Maržić, Diana, Blažen Marijić, Tamara Braut, Stefan Janik, Manuela Avirović, Ita Hadžisejdić, Filip Tudor, Katarina Radobuljac, Miran Čoklo and Boban M. Erovic. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers 13, no. 17 (2021). https://doi.org/10.3390/cancers13174306

Maržić, D., et al. (2021) 'IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma', Cancers, 13(17). doi: 10.3390/cancers13174306

Maržić D, Marijić B, Braut T, Janik S, Avirović M, Hadžisejdić I, and sur.. IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers [Internet]. 2021 August 26 [cited 2024 May 17];13(17). doi: 10.3390/cancers13174306

D. Maržić, et al., "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma", Cancers, vol. 13, no. 17, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:958258. [Accessed: 17 May 2024]

Metadata
Title (english)IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
AuthorDiana Maržić
AuthorBlažen Marijić
AuthorTamara Braut
AuthorStefan Janik
AuthorManuela Avirović
AuthorIta Hadžisejdić
AuthorFilip Tudor https://orcid.org/0000-0001-6386-0444
AuthorKatarina Radobuljac
AuthorMiran Čoklo
AuthorBoban M. Erovic
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Background: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules). Results: IMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (p < 0.001; p < 0.001, respectively). Similarly, higher expression patterns were observed for Ki-67 and p53, whereas cyclin D1 was equally distributed in all three lesions. IMP3 (p = 0.04) and Ki-67 (p = 0.02) expressions were significantly linked to neck node positivity, and IMP3 overexpression to worse disease-specific survival (p = 0.027). Conclusion: Since IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCancers
Numberingvol. 13, no. 17, 4306
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13174306
URN:NBNurn:nbn:hr:184:958258
Publication2021-08-26
ProjectNumber: uniri-biomed-18-121
Title (croatian): Molekularni biomarkeri kancerogeneze u skvamoznim epitelnim lezijama grkljana
Title (english): Molecular biomarkers of cancerogenesis in laryngeal squamous epithelial lesions
Leader: Tamara Braut
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: uniri-biomed-18-242
Title (croatian): Klinički značaj niske razine JAK2 V617F mutacije u perifernoj krvi: utjecaj na fenotip i prognozu
Title (english): Clinical significance of low level JAK2 V617F mutation in peripheral blood: effect on phenotype and prognosis
Leader: Ita Hadžisejdić
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttps://www.mdpi.com/2072-6694/13/17/4306
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-10-26 12:13:04