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Scientific paper - Original scientific paper
Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss
Psychiatria Danubina, 33 (2021), 4; 719-731. urn:nbn:hr:184:612607
Ružić Baršić, Antonija; Gudelj, Lea; Antulov, Ronald; Miletić, Damir; Knežević, Koraljka; Rubeša, Gordana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Ružić Baršić, A., Gudelj, L., Antulov, R., Miletić, D., Knežević, K. & Rubeša, G. (2021). Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss. Psychiatria Danubina, 33. (4), 719-731. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, Antonija, et al. "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss." Psychiatria Danubina, vol. 33, no. 4, 2021, pp. 719-731. https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, Antonija, Lea Gudelj, Ronald Antulov, Damir Miletić, Koraljka Knežević and Gordana Rubeša. "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss." Psychiatria Danubina 33, no. 4 (2021): 719-731. https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, A., et al. (2021) 'Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss', Psychiatria Danubina, 33(4), pp. 719-731. Available at: https://urn.nsk.hr/urn:nbn:hr:184:612607 (Accessed 14 March 2025)

Ružić Baršić A, Gudelj L, Antulov R, Miletić D, Knežević K, Rubeša G. Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss. Psychiatria Danubina [Internet]. 2021 [cited 2025 March 14];33(4):719-731. Available at: https://urn.nsk.hr/urn:nbn:hr:184:612607

A. Ružić Baršić, L. Gudelj, R. Antulov, D. Miletić, K. Knežević and G. Rubeša, "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss", Psychiatria Danubina, vol. 33, no. 4, pp. 719-731, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:612607. [Accessed: 14 March 2025]

Metadata
Title (english)Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss
AuthorAntonija Ružić Baršić
AuthorLea Gudelj
MBZ: 163231
AuthorRonald Antulov
MBZ: 269975
AuthorDamir Miletić
AuthorKoraljka Knežević
AuthorGordana Rubeša
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Psychiatry and Psychological Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Radiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiology
Abstract (english)
Background: Brain maturation is considered completed around the age of 25, when prefrontal cortex maturation has been achieved. The aim of our study was to investigate the alterations of grey matter (GM) in patients with the onset of schizophrenia before and after the completion of brain maturation. Subjects and methods: The study group included 100 schizophrenia patients, while the control group comprised 50 healthy individuals. Brain magnetic resonance imaging was acquired on a 1.5 T scanner. Voxel-based morphometry (VBM) analyses were performed between groups. Results: GM of the schizophrenic patients is reduced in many regions (p<0.005 FDR corrected). Most widespread reduction is detected in frontal cortex and cerebellum, the other regions being limbic cortex, insula, cuneus, precuneus, superior temporal gyrus and motor cortex. The decrease of grey matter volume (GMV) increases with the increase in number of psychotic episodes and is more pronounced in the patients with earlier onset of the disease. Conclusions: The age of the onset of the disease is important for both total and relative loss of GMV. Earlier onset of schizophrenia, prior to full brain maturation results in significant reduction of GM in comparison with healthy subjects and patients with later, post full brain maturation onset of the disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePsychiatria Danubina
Numberingvol. 33, no. 4, pp. 719-731
p-ISSN0353-5053
URN:NBNurn:nbn:hr:184:612607
Publication2021
Document URLhttp://bib.irb.hr/1154794
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-27 15:20:39