prikaz prve stranice dokumenta Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
  Download
PDF 407.77 KB
Scientific paper - Original scientific paper
Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
Biomedical Reports, 16 (2021), 2; 12. https://doi.org/10.3892/br.2021.1495
Čizmarević, Nada; Ćurko‑Cofek, Božena; Barac-Latas, Vesna; Peterlin, Borut; Ristić, Smiljana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Čizmarević, N., Ćurko‑Cofek, B., Barac Latas, V., Peterlin, B. & Ristić, S. (2021). Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis. Biomedical Reports, 16. (2). doi: 10.3892/br.2021.1495

Čizmarević, Nada, et al. "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis." Biomedical Reports, vol. 16, no. 2, 2021. https://doi.org/10.3892/br.2021.1495

Čizmarević, Nada, Božena Ćurko‑Cofek, Vesna Barac Latas, Borut Peterlin and Smiljana Ristić. "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis." Biomedical Reports 16, no. 2 (2021). https://doi.org/10.3892/br.2021.1495

Čizmarević, N., et al. (2021) 'Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis', Biomedical Reports, 16(2). doi: 10.3892/br.2021.1495

Čizmarević N, Ćurko‑Cofek B, Barac Latas V, Peterlin B, Ristić S. Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis. Biomedical Reports [Internet]. 2021 December 17 [cited 2024 April 27];16(2). doi: 10.3892/br.2021.1495

N. Čizmarević, B. Ćurko‑Cofek, V. Barac Latas, B. Peterlin and S. Ristić, "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis", Biomedical Reports, vol. 16, no. 2, December 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:609991. [Accessed: 27 April 2024]

Metadata
Title (english)Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
AuthorNada Čizmarević
AuthorBožena Ćurko‑Cofek
AuthorVesna Barac-Latas
AuthorBorut Peterlin
AuthorSmiljana Ristić
MBZ: 142283
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Increasing evidence supports the potential role of iron metabolism in multiple sclerosis (MS). Previous studies examining the association between polymorphisms of the hemochromatosis gene (HFE) and susceptibility to MS have yielded inconsistent results. In the present study, a meta‑anal‑ ysis of 7 studies was performed conducted in populations of Caucasian origin using the Comprehensive Meta‑analysis 3.0 software. The strength of association between the C282Y and H63D polymorphisms in HFE and MS risk was estimated by odds ratios with 95% confidence intervals. Cochran's Q statistic and I2 tests were applied to quantify heterogeneity between studies. An Egger's test was used to estimate publication bias. The C282Y and H63D polymorphisms had no significant asso‑ ciation with increased MS risk (all P≥0.05) in the following genetic comparison models: Dominant model (YY + CY vs. CC or DD + HD vs. HH) and allele contrast (Y vs. C or D vs. H). No apparent publication bias or significant heteroge‑ neity was found between studies. These results suggest that the HFE polymorphisms C282Y and H63D are not associated with susceptibility to MS in populations of Caucasian origin. Further studies should be performed in a larger series of MS patients to evaluate the contribution of HFE and other genetic variants associated with iron regulation in the development and progression of MS
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedical Reports
Numberingvol. 16, no. 2, 12
p-ISSN2049-9434
e-ISSN2049-9442
DOIhttps://doi.org/10.3892/br.2021.1495
URN:NBNurn:nbn:hr:184:609991
Publication2021-12-17
ProjectNumber: uniri-biomed-18-137
Title (croatian): Farmakogenetika multiple skleroze:odgovor na imunomodulacijsku terapiju
Title (english): Farmacogenetics of multiple sclerosis: response to disease-modifying therapy
Leader: Nada Starčević Čizmarević
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://www.spandidos-publications.com/10.3892/br.2021.1495
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-06-17
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-01 12:06:16