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Professional paper - Review paper
„Non-culture" methods in diagnostics of invasive candidiasis
Infektološki glasnik, 41 (2021), 2; 57-65. https://doi.org/10.37797/ig.41.2.4
Ratković, Dea; Abram, Maja; Bubonja-Šonje, Marina

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Ratković, D., Abram, M. & Bubonja Šonje, M. (2021). „Non-culture" methods in diagnostics of invasive candidiasis. Infektološki glasnik, 41. (2), 57-65. doi: 10.37797/ig.41.2.4

Ratković, Dea, et al. "„Non-culture" methods in diagnostics of invasive candidiasis." Infektološki glasnik, vol. 41, no. 2, 2021, pp. 57-65. https://doi.org/10.37797/ig.41.2.4

Ratković, Dea, Maja Abram and Marina Bubonja Šonje. "„Non-culture" methods in diagnostics of invasive candidiasis." Infektološki glasnik 41, no. 2 (2021): 57-65. https://doi.org/10.37797/ig.41.2.4

Ratković, D., Abram, M. and Bubonja Šonje, M. (2021) '„Non-culture" methods in diagnostics of invasive candidiasis', Infektološki glasnik, 41(2), pp. 57-65. doi: 10.37797/ig.41.2.4

Ratković D, Abram M, Bubonja Šonje M. „Non-culture" methods in diagnostics of invasive candidiasis. Infektološki glasnik [Internet]. 2021 [cited 2024 July 25];41(2):57-65. doi: 10.37797/ig.41.2.4

D. Ratković, M. Abram and M. Bubonja Šonje, "„Non-culture" methods in diagnostics of invasive candidiasis", Infektološki glasnik, vol. 41, no. 2, pp. 57-65, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:057733. [Accessed: 25 July 2024]

Metadata
Title (english)„Non-culture" methods in diagnostics of invasive candidiasis
Title (croatian)Nekultivacijske metode u dijagnostici invazivne kandidijaze
AuthorDea Ratković
AuthorMaja Abram
AuthorMarina Bubonja-Šonje
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Invasive fungal infections, especially those caused by Candida species, are not uncommon in critically ill patients and are associated with significant morbidity and mortality. Early diagnosis is essential because delaying the use of antifungal drugs can affect treatment outcome. Due to the limitations of classical culture-based methods (they are time-consuming and insensitive), trends in diagnostics switch to “non-culture” based methods for early diagnosis of invasive candidiasis. „Non-culture" methods, such as biomarker detection or Polymerase Chain Reaction (PCR) techniques, have great diagnostic potential. For example, a negative PCR or 1,3-β-D-glucan (BDG) test result have a high negative predictive value (NPV). In order to increase the reliability of each method, it is recommended to combine different methods as well as to interpret the obtained results in accordance with the clinical, epidemiological, laboratory and other patient data.
Abstract (croatian)
Invazivne gljivične infekcije uzrokovane vrstama iz roda Candida česte su u kritično oboljelih bolesnika i povezane su sa značajnim morbiditetom i mortalitetom. Pravovremeno postavljanje dijagnoze je od presudnog značaja budući da svako odgađanje primjene antifungalnih lijekova utječe na ishod liječenja. Zbog ograničenja klasičnih dijagnostičkih metoda zasnovanih na kultivaciji - njihove sporosti i nedovoljne osjetljivosti, nekultivacijske imunološke i molekularne dijagnostičke metode sve više nalaze svoje mjesto u dijagnostici invazivne kandidijaze. Nekultivacijske metode, kao što je određivanje biomarkera ili lančana reakcija polimeraze (engl. Polymerase Chain Reaction, PCR) imaju veliki dijagnostički potencijal. Primjerice, negativan rezultat PCR testa ili 1,3-β-D-glukana (BDG) ima visoku negativnu prediktivnu vrijednost (NPV) tj. veliku vjerojatnost odsustva bolesti. U svrhu povećanja pouzdanosti pojedine metode preporučuje se kombiniranje različitih metoda kao i tumačenje dobivenih rezultata u skladu s kliničkim, epidemiološkim, laboratorijskim i drugim podatcima.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInfektološki glasnik
Numberingvol. 41, no. 2, pp. 57-65
p-ISSN1331-2820
e-ISSN1848-7769
DOIhttps://doi.org/10.37797/ig.41.2.4
URN:NBNurn:nbn:hr:184:057733
Publication2021
Document URLhttps://hrcak.srce.hr/270533
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-02-09 14:28:48