prikaz prve stranice dokumenta Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
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Scientific paper - Original scientific paper
Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
Food and Chemical Toxicology, 121 (2018), -; 140-150. urn:nbn:hr:184:921774
Vukelić, Iva; Detel, Dijana; Batičić Pučar, Lara; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vukelić, I., Detel, D., Batičić Pučar, L., Potočnjak, I., Buljević, S. & Domitrović, R. (2018). Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food and Chemical Toxicology, 121. (-), 140-150. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, Iva, et al. "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis." Food and Chemical Toxicology, vol. 121, no. -, 2018, pp. 140-150. https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, Iva, Dijana Detel, Lara Batičić Pučar, Iva Potočnjak, Sunčica Buljević and Robert. Domitrović. "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis." Food and Chemical Toxicology 121, no. - (2018): 140-150. https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, I., et al. (2018) 'Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis', Food and Chemical Toxicology, 121(-), pp. 140-150. Available at: https://urn.nsk.hr/urn:nbn:hr:184:921774 (Accessed 05 May 2024)

Vukelić I, Detel D, Batičić Pučar L, Potočnjak I, Buljević S, Domitrović R. Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food and Chemical Toxicology [Internet]. 2018 [cited 2024 May 05];121(-):140-150. Available at: https://urn.nsk.hr/urn:nbn:hr:184:921774

I. Vukelić, D. Detel, L. Batičić Pučar, I. Potočnjak, S. Buljević and R. Domitrović, "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis", Food and Chemical Toxicology, vol. 121, no. -, pp. 140-150, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:921774. [Accessed: 05 May 2024]

Metadata
Title (english)Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
AuthorIva Vukelić
AuthorDijana Detel
AuthorLara Batičić Pučar
AuthorIva Potočnjak
AuthorSunčica Buljević
AuthorRobert. Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract (english)
Chlorogenic acid (ChA) exhibits a multitude of positive health effects, however, the signaling mechanisms by which ChA could influence the inflammatory response in experimental colitis are unknown. To answer this question, we induced colitis in mice by administration of 2.5% dextran sulfate sodium (DSS) in drinking water for seven days. Oral administration of ChA significantly ameliorated clinical symptoms, improved disease activity index and colon shortening induced by DSS. Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Immunohistochemical analysis showed a dose- dependent decrease in expression and nuclear translocation of nuclear factor-kappa B (NF-κB) p65 subunit, which was accompanied by suppression of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) expression. Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase- 8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in mice administrated with ChA. The results of the current study suggest that ChA could be useful for the treatment of inflammation and attenuating colitis severity by suppressing activation of pro-inflammatory and apoptotic signaling pathways.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFood and Chemical Toxicology
Numberingvol. 121, no. -, pp. 140-150
p-ISSN0278-6915
URN:NBNurn:nbn:hr:184:921774
Publication2018
Document URLhttp://bib.irb.hr/955144
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-10 12:43:16